{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:12:10Z","timestamp":1787879530895,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Porocarcinomas are rare aggressive carcinomas that harbor tumor suppressor mutations and must be distinguished from benign entities such as poromas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To determine whether altered expression of these genes was diagnostically informative, we examined p53, Rb, and p16 staining patterns in 15 poromas and 16 porocarcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Poromas consistently displayed diffuse strong expression of Rb in all but one case that displayed focal loss (1\/15, 7%), and no evidence of aberrancy in p53 or p16. Porocarcinomas displayed diffuse or focal loss of Rb expression in 9\/16 (56%) cases, diffuse loss or overexpression of p53 in 8\/15 (53%), and diffuse loss or overexpression of p16 in 6\/14 (43%). Diffuse aberrancy in p53 and Rb expression correlated with tumor mutations in <jats:italic>TP53<\/jats:italic> and <jats:italic>RB1<\/jats:italic>, respectively, whereas focal Rb loss was associated with wild type <jats:italic>RB1<\/jats:italic>. Diffuse p16 overexpression correlated with Rb loss rather than <jats:italic>CDKN2A<\/jats:italic> mutation. For porocarcinomas with all three stains evaluable, 10\/13 (77%) displayed aberrancy in at least one marker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that altered p53, p16, and\/or Rb expression is relatively specific to porocarcinoma in comparison with poroma. Technical limitations of this panel, including possible focal Rb loss, must be kept in mind, especially in limited samples.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13480","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T05:21:51Z","timestamp":1555996911000},"page":"659-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma"],"prefix":"10.1111","volume":"46","author":[{"given":"Joseph","family":"Zahn","sequence":"first","affiliation":[{"name":"Department of Pathology Michigan Medicine  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-1266","authenticated-orcid":false,"given":"May P.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine  Ann Arbor 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