{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T22:42:44Z","timestamp":1778193764300,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>We describe a patient with thrombocytopenia\u2010absent radius (TAR) syndrome, multisystemic Langerhans cell histiocytosis and multiple reticulohistiocytomas. A mutational study by massive sequencing identified the Val600Glu (V600E) <jats:italic>BRAF<\/jats:italic> mutation in the Langerhans cell histiocytosis lesions, but no molecular alterations were found in the reticulohistiocytoma lesions. The concomitant presence in the same patient of more than one type of histiocytosis from two different groups recognized in the most recent Histiocyte Society classification is an extremely rare event. Our case is the first reported case of multisystemic Langerhans cell histiocytosis and multiple reticulohistiocytomas in a patient with TAR syndrome.<\/jats:p>","DOI":"10.1111\/cup.13483","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T06:54:30Z","timestamp":1555916070000},"page":"609-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Langerhans cell histiocytosis and multiple reticulohistiocytomas in a patient with TAR syndrome:  An association not previously described"],"prefix":"10.1111","volume":"46","author":[{"given":"Luc\u00eda N.","family":"Hip\u00f3lito","sequence":"first","affiliation":[{"name":"Department of Dermatology Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda 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