{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:16:32Z","timestamp":1778498192119,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["DP5 OD021403"],"award-info":[{"award-number":["DP5 OD021403"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sebaceous carcinoma (SeC) is an uncommon malignancy arising from sebaceous glands of the conjunctiva and skin. Recurrent mutations in the <jats:italic>ZNF750<\/jats:italic> were recently identified in ocular SeC. We assessed whether ZNF750 loss is a specific feature of ocular SeC or a general feature of sebaceous tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunostaining for ZNF750 expression was performed in 54 benign and malignant sebocytic proliferations. Staining for ZNF750 was scored on a three\u2010tier scale: positive (&gt;75%), partially positive (5%\u201074%), and negative (&lt;5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ZNF750 expression was negative in 4\/11 ocular SeC, and partially positive in 4\/11 ocular SeC and 6\/13 cutaneous SeC. No extraocular tumors were negative. No loss was found in sebaceous adenoma or sebaceous hyperplasia. In nine previously sequenced ocular SeCs, two lacked detectable somatic mutations in <jats:italic>ZNF750,<\/jats:italic> but showed complete loss of staining, indicating non\u2010mutational inactivation of ZNF750.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We show complete loss of the ZNF750 epidermal differentiation regulator in about half of ocular SeC, highlighting the most common genetic defect in this cancer type. Loss of ZNF750 expression is seen even in tumors without truncating mutations and reduced in many of the remaining ocular and cutaneous SeC. In contrast, no ZNF750 loss was detected in benign sebaceous proliferations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13516","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T04:14:31Z","timestamp":1559276071000},"page":"736-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-5314","authenticated-orcid":false,"given":"Jeffrey P.","family":"North","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California, San Francisco  San Francisco California"},{"name":"Department of Pathology University of California, San Francisco  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, San Francisco  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Golovato","sequence":"additional","affiliation":[{"name":"NantOmics, LLC  Santa Cruz California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Bloomer","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, San Francisco  San Francisco California"},{"name":"Department of Ophthalmology University of California, San Francisco  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Benz","sequence":"additional","affiliation":[{"name":"NantOmics, LLC  Santa Cruz California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6090-6603","authenticated-orcid":false,"given":"Raymond J.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California, San Francisco  San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23952"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000152"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.054"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04008-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4759"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.12.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1813"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.377"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1688"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2935"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.035"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114669108"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.29458"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.246579.114"},{"issue":"566","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.18632\/oncotarget.23075","article-title":"Pathway\u2010focused 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