{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:13:38Z","timestamp":1792034018012,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A cutaneous melanocytic tumor with morphologic overlap with clear cell sarcoma, but defined by <jats:italic>CRTC1\u2010TRIM11<\/jats:italic> gene fusion, was recently described in a series of five adult patients. Here, we expand the clinicopathologic features of this entity by four additional cases which include pediatric presentation, exophytic growth, and propensity to occur on the head. Patients (2F; 2M) had a median age of 41 years (range 11\u201059). Sites of involvement included leg, ear, and face. Tumors were circumscribed, unencapsulated, mostly limited to the dermis, and varied from 5 to 35\u2009mm. One case was exophytic. Lesional cells were arranged in nests and fascicles, and were monomorphic and fusiform with moderate pale to clear cytoplasm, occasional nuclear pseudo\u2010inclusions, and small to prominent nucleoli. Mitotic rate was variable (rare to 12\/10 HPF, median 3\/10 HPF). The pediatric case showed increased nuclear pleomorphism, tumor necrosis, and mitotic figures. All cases showed strong, diffuse nuclear staining for SOX10, but were negative or focal for S100 protein, HMB45 and Melan\u2010A expression. Cases were positive by FISH technique and\/or RNA sequencing for a <jats:italic>TRIM11<\/jats:italic> rearrangement\/fusion, and negative for <jats:italic>EWSR1<\/jats:italic> rearrangement. This series is presented to aid in further characterization of this novel melanocytic tumor.<\/jats:p>","DOI":"10.1111\/cup.13533","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T21:34:14Z","timestamp":1561498454000},"page":"810-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["<i>CRTC1\u2010TRIM11<\/i> fusion defined melanocytic tumors: A series of four cases"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-775X","authenticated-orcid":false,"given":"Jennifer S.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland 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Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-8241","authenticated-orcid":false,"given":"Arnaud","family":"De La Fouchardiere","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1 Research Cancer Center of Lyon  Lyon 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