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Shave biopsy and immunohistochemical studies revealed that the tumor was composed of melanoma (highlighted by SOX10 and MART\u20101, with high Ki\u201067 proliferative index) intermixed with nodular basal cell carcinoma (highlighted by pan\u2010cytokeratin and Ber\u2010EP4). The neoplastic melanocytes were confined to the basal cell carcinoma nodules, and a diagnosis of combined melanoma in situ and basal cell carcinoma was rendered. After therapeutic excision, the patient was disease\u2010free at 9\u2009months after the initial diagnosis. The second tumor presented as a 6\u2010mm pink\u2010brown crusted papule on the right forehead in an 89\u2010year\u2010old man. Shave biopsy and immunohistochemical studies revealed that the tumor was composed of malignant melanoma (MM) (highlighted by S100 and MART\u20101) intermixed with squamous cell carcinoma (SCC) (highlighted by cytokeratin and p63), and a diagnosis of combined MM\u2010SCC was rendered. These two cases highlight the importance of recognizing these rare types of melanocytic\u2010epithelial cutaneous neoplasms to arrive at an accurate diagnosis that may inform appropriate disease stage and therapy.<\/jats:p>","DOI":"10.1111\/cup.13551","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T15:48:51Z","timestamp":1564501731000},"page":"36-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cutaneous neoplasms composed of melanoma and carcinoma: A rare but important diagnostic pitfall and review of the literature"],"prefix":"10.1111","volume":"47","author":[{"given":"Haider A.","family":"Mejbel","sequence":"first","affiliation":[{"name":"Department of Pathology East Tennessee State University  Johnson City Tennessee"},{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston 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