{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:07:33Z","timestamp":1766268453818,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>S\u00e9zary syndrome (SS) and erythrodermic mycosis fungoides (E\u2010MF) represent two expressions of erythrodermic cutaneous T\u2010cell lymphoma (E\u2010CTCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histopathologic features were compared on skin specimens from 41 patients with SS and 70 patients with E\u2010MF. Immunopathologic findings were compared on 42 SS and 79 E\u2010MF specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Specimens of SS usually showed band\u2010like dermal infiltrates with intermediate\u2010sized lymphoid cells and few plasma cells; on the other hand E\u2010MF more often had a perivascular infiltrative pattern, predominance of small\/mixed lymphoid cells and eosinophils. SS also had lower numbers of CD8+ cells and higher numbers of CD62L+ cells compared to E\u2010MF. For E\u2010MF patients, the presence of large Pautrier collections, infiltrates with intermediate\u2010sized cells, increased number of mitotic figures and \u226550% CD62L+ cells in the dermal infiltrate correlated with a relatively poor disease\u2010specific survival. However, only the presence of mitotic figures retained prognostic significance with clinical stage as a covariate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical stage provides the most important prognostic information for patients with E\u2010CTCL. However, mitotic activity for E\u2010MF and CD8+ cells &lt;20% for SS have additional value. We hypothesize that observed differences in plasma cell and eosinophil numbers may reflect the influence of CD62L+ central memory T\u2010cells in the microenvironment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13564","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T10:39:57Z","timestamp":1565606397000},"page":"913-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A histo\u2010immunopathologic and prognostic study of erythrodermic cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-3403","authenticated-orcid":false,"given":"Eric C.","family":"Vonderheid","sequence":"first","affiliation":[{"name":"Sydney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutes  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary R.","family":"Kantor","sequence":"additional","affiliation":[{"name":"Dermatopathologist, Dermpath Diagnostics Institute for Dermatopathology  Newtown Square Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys H.","family":"Telang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Warren Alpert Medical School of Brown University  Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Bujanouskas","sequence":"additional","affiliation":[{"name":"Mid\u2010Atlantic Permanente Medical Group  Falls Church Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall E.","family":"Kadin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Boston University and Roger Williams Medical Center  Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_7_3_1","first-page":"226","volume-title":"WHO Classification of Skin Tumours","author":"Cerroni L","year":"2018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0630"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.01.076"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1334123"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9554.1000452"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)80321-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb00794.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01766.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70294-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181cfbfbf"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13832"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70277-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600709655"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118538"},{"volume-title":"Modelling Survival Data in Medical Research","year":"1997","author":"Collett D","key":"e_1_2_7_17_1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb00793.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12305"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.109853"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-480889"},{"issue":"5","key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.4049\/jimmunol.134.5.2995","article-title":"Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti\u2010leu\u20108","volume":"134","author":"Kansas GS","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70124-2"},{"issue":"6","key":"e_1_2_7_24_1","first-page":"859","article-title":"Abnormalities of circulating T\u2010cell subpopulations in patients with cutaneous T\u2010cell lymphoma: cutaneous lymphocyte\u2010associated antigen expression on T cells correlates with extent of disease","volume":"7","author":"Borowitz MJ","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00259.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.10.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01068"},{"issue":"6","key":"e_1_2_7_28_1","first-page":"1688","article-title":"The human peripheral lymph node vascular addressin. 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