{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:58Z","timestamp":1747184278440,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>El Bagre endemic pemphigus foliaceus (El Bagre\u2010EPF) is a new variant of endemic pemphigus foliaceus present in the El Bagre area of Colombia, South America. Here, we investigate the presence of complement\/C5\u2010b9 in lesional skin of patients and matched controls from the endemic area. We also aim to compare the patient's autoantibody levels using indirect immunofluorescent titers (IIF) and correlate with the lesional presence of complement\/C5b\u20109.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study was carried out by testing for the presence of complement\/C5b\u20109 in lesional skin in 43 patients affected by El Bagre\u2010EPF, as well as 43 matched, healthy controls from the endemic area. Skin biopsies were obtained and evaluated via hematoxylin and eosin staining, and immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of complement\/C5b\u20109 was observed in all cases of the patients affected by El Bagre\u2010EPF and was not observed in the controls from the endemic area (<jats:italic>P<\/jats:italic> &lt;\u20090.001). The patients' autoantibody titers utilizing IIF for IgG and IgM showed correlation between higher autoantibody titers and stronger intensity of staining with complement\/C5\u2010b9 staining (<jats:italic>P<\/jats:italic> &lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients affected by El Bagre\u2010EPF have lesional deposition of complement\/C5b, which correlates with disease severity and previously established serologies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13565","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T01:58:51Z","timestamp":1566439131000},"page":"925-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Membrane attack complex (C5b\u20109 complex or Mac), is strongly present in lesional skin from patients with endemic pemphigus foliaceus in El Bagre, Colombia"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-4133","authenticated-orcid":false,"given":"Ana Maria","family":"Abreu\u2010Velez","sequence":"first","affiliation":[{"name":"Georgia Dermatopathology Associates  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulieth A.","family":"Upegui\u2010Zapata","sequence":"additional","affiliation":[{"name":"School of Medicine Medical Research Institute, University of Antioquia  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Valencia\u2010Yepes","sequence":"additional","affiliation":[{"name":"Department of Education University of Antioquia  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Upegui\u2010Quiceno","sequence":"additional","affiliation":[{"name":"Programa de Estudio y Control de Enfermedades Tropicales Group, University of Antioquia  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia\u2010Regina","family":"Mesa\u2010Herrera","sequence":"additional","affiliation":[{"name":"Biogemol Institute and Department of Physiology and Biochemistry School of Medicine University of Antioquia  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra M.","family":"Jim\u00e9nez\u2010Echavarria","sequence":"additional","affiliation":[{"name":"Programa de Estudio y Control de Enfermedades Tropicales Group, University of Antioquia  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar D. N.","family":"Pulido","sequence":"additional","affiliation":[{"name":"Department of Cardiology CES University  Medellin Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce R.","family":"Smoller","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester School of Medicine and Dentistry  Rochester New York"},{"name":"Department of Dermatology University of Rochester School of Medicine and Dentistry  Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Howard","sequence":"additional","affiliation":[{"name":"Georgia Dermatopathology Associates  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000254290"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"432","article-title":"Localization of complement in epithelium by means of immunofluorescence in patients with pemphigus. 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