{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:41:38Z","timestamp":1778845298834,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pigmented epithelioid melanocytoma (PEM) represents a group of rare, heavily pigmented melanocytic tumors encompassing lesions previously designated as \u201canimal\u2010type melanomas\u201d and \u201cepithelioid blue nevi.\u201d Despite the association of multiple such tumors in the setting of Carney complex, most cases of PEM occur spontaneously as solitary neoplasms in otherwise healthy patients. PEM may arise in both children and adults, and has a known propensity to spread to the regional lymph nodes. Despite this latter finding, recurrence at the biopsy site or spread beyond the lymph node basin is exceptionally uncommon. Although the molecular basis for PEM continues to be characterized, findings to date suggest that this category of melanocytic neoplasia has genetic alterations distinct from those seen in common nevi, dysplastic nevi, Spitz nevi, and melanoma. Herein, we present an in\u2010depth clinical, histopathologic, and molecular analysis of a case of PEM occurring on the scalp of a young African American girl found to have a novel <jats:italic>NTRK3\u2010SCAPER<\/jats:italic> gene fusion.<\/jats:p>","DOI":"10.1111\/cup.13566","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T16:22:35Z","timestamp":1566490955000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel <i>NTRK3\u2010SCAPER<\/i> gene fusion"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0075-836X","authenticated-orcid":false,"given":"Ben J.","family":"Friedman","sequence":"first","affiliation":[{"name":"Department of Dermatology Henry Ford Health System  Detroit Michigan"},{"name":"Department of Pathology and Laboratory Medicine Henry Ford Health System  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Hernandez","sequence":"additional","affiliation":[{"name":"College of Medicine State University of New York Upstate Medical University  Syracuse New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea","family":"Fidai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Health System  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Health System  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor A.","family":"Shwayder","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Health System  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Carskadon","sequence":"additional","affiliation":[{"name":"Department of Urology Vattikuti Urology Institute, Henry Ford Health System  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleodor A.","family":"Andea","sequence":"additional","affiliation":[{"name":"Department of Pathology, Michigan Medicine University of Michigan  Ann Arbor Michigan"},{"name":"Department of Dermatology, Michigan Medicine University of Michigan  Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-2883","authenticated-orcid":false,"given":"Paul W.","family":"Harms","sequence":"additional","affiliation":[{"name":"Department of Pathology, Michigan Medicine University of Michigan  Ann Arbor Michigan"},{"name":"Department of Dermatology, Michigan Medicine University of Michigan  Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhananjay","family":"Chitale","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Henry Ford Health System  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-9772","authenticated-orcid":false,"given":"Nallasivam","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"Department of Urology Vattikuti Urology Institute, Henry Ford Health System  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-008865"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14322"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00313021003631213"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000902"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001195"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63536-5"},{"issue":"10","key":"e_1_2_6_9_1","first-page":"2170","article-title":"Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization","volume":"58","author":"Bastian 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