{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:55:18Z","timestamp":1790286918414,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nivolumab and pembrolizumab are humanized IgG4 monoclonal antibodies against programmed cell death 1 (PD\u20101). Although these agents are effective in treating advanced melanoma, non\u2010small\u2010cell lung carcinoma, and other types of cancers, various adverse events have been reported. Cutaneous adverse events are particularly prevalent and, while granulomatous\/sarcoid\u2010like reactions are uncommon, they are increasingly recognized as immune\u2010related adverse events associated with immune checkpoint inhibitors. Herein, we report two cases of granulomatous\/sarcoid\u2010like reaction with foreign material, mimicking metastatic malignancy after PD\u20101 inhibitor treatment. Clinicians should be aware of the existence of cutaneous lesions and perform biopsy if needed to prevent misdiagnosis and unnecessary adjustments to immunotherapy.<\/jats:p>","DOI":"10.1111\/cup.13569","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T16:27:17Z","timestamp":1566491237000},"page":"154-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Granulomatous\/sarcoid\u2010like reactions in the setting of programmed cell death\u20101 inhibition: a potential mimic of disease recurrence"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-1565","authenticated-orcid":false,"given":"Tsubasa","family":"Hiraki","sequence":"first","affiliation":[{"name":"Department of Pathology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"},{"name":"Department of Surgical Pathology Kagoshima University Hospital  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Arimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Kawahira","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kirishima","sequence":"additional","affiliation":[{"name":"Department of Pathology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"},{"name":"Department of Surgical Pathology Kagoshima University Hospital  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Kitazono","sequence":"additional","affiliation":[{"name":"Department of Pathology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Horinouchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyo","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"},{"name":"Department of Surgical Pathology Kagoshima University Hospital  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Kanekura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Kagoshima University Graduate School of Medical and Dental Sciences  Sakuragaoka Kagoshima Japan"},{"name":"Department of Surgical Pathology Kagoshima University Hospital  Sakuragaoka Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503093"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv383"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2016.12.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2018.01.020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.10.029"},{"issue":"18","key":"e_1_2_6_8_1","first-page":"32355","article-title":"Immune checkpoint inhibitors and the development of granulomatous reactions","volume":"0190","author":"Cornejo CM","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2016.05.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14781"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2017.02.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000437"},{"issue":"2016","key":"e_1_2_6_13_1","article-title":"Systemic sarcoidosis first manifesting in a tattoo in the setting of immune checkpoint inhibition","volume":"26","author":"Kim C","year":"2016","journal-title":"BMJ Case Rep"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2016.06.004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0323-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.05.032"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13076"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.08.753"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000181"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000266"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2017.11.008"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155216667635"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2015.10.082"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12380"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00107912"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000161122"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000213245"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.028"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2017.027383"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30252-3"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0581"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0372-4"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2017.06.014"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13044"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14617"},{"issue":"1","key":"e_1_2_6_36_1","first-page":"256","article-title":"Granuloma annulare in the setting of ipilimumab therapy","volume":"6","author":"Haselden VNVR","year":"2015","journal-title":"J Clin Exp Dermatol Res"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13267"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13540"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13133"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14674"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13307"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.70"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201401-0188OC"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0037OC"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197503)35:3<756::AID-CNCR2820350331>3.0.CO;2-Z"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13569","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:50:44Z","timestamp":1694166644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/cup.13569"],"URL":"https:\/\/doi.org\/10.1111\/cup.13569","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2019-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}