{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:37:03Z","timestamp":1790473023269,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The phenomenon of histiocytic\/dendritic cell sarcomas arising through transformation of a pre\u2010existed lymphoproliferative disease is called transdifferentiation. Langerhans cell sarcoma transdifferentiating from chronic lymphocytic leukemia\/small lymphocytic lymphoma is extremely rare and all the reported cases were localized in lymph nodes. We present a case of concurrent cutaneous localization of Langerhans cell sarcoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma, in which the chronic lymphocytic leukemia\/small lymphocytic lymphoma preceded the development of the Langerhans cell sarcoma. A cutaneous lesion from a 63\u2010year\u2010old patient with a history of chronic lymphocytic leukemia\/small lymphocytic lymphoma was biopsied. The histologic examination revealed a mixture of two cell populations infiltrating diffusely the dermis. The first was composed of small lymphoid cells with somewhat monotonous appearance and mild nuclear atypia positive for PAX5, CD79a, CD20, CD23, CD5, and LEF1. The second was composed of large cells with abundant cytoplasm and pleomorphic nuclei. These cells were positive for CD1a, CD207, and S100 protein and exhibited a high mitotic rate and a high MIB\u20101 immunostaining index. Therefore, two different entities, chronic lymphocytic leukemia\/small lymphocytic lymphoma and Langerhans cell sarcoma, were detected in the same skin fragment. The patient died 3\u2009years after initial diagnosis of chronic lymphocytic leukemia\/small lymphocytic lymphoma.<\/jats:p>","DOI":"10.1111\/cup.13571","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T15:24:16Z","timestamp":1566573856000},"page":"161-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Concurrent cutaneous localization of Langerhans cell sarcoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma in a patient with a history of chronic lymphocytic leukemia\/small lymphocytic lymphoma"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3932-6652","authenticated-orcid":false,"given":"Alexandra","family":"Papoudou\u2010Bai","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, School of Health Sciences University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Vassou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, School of Health Sciences University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Marinos","sequence":"additional","affiliation":[{"name":"Department of Hematopathology Evangelismos General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Papathanasiou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, School of Health Sciences University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Kapsali","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, School of Health Sciences University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Kanavaros","sequence":"additional","affiliation":[{"name":"Department of Anatomy\u2010Histology\u2010Embryology, Faculty of Medicine, School of Health Sciences University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.180"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2015.09.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0104-RS"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428191003699845"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0300-y"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.5858\/2006-130-544-SIDCSA","article-title":"Synchronous 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