{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:15:42Z","timestamp":1789031742976,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metastatic carcinoma to the skin occurs in only a minority of patients with a visceral or internal malignancy, with breast, lung, and colorectum accounting for the majority of cases. We present the case of a 66\u2010year\u2010old man with a recent violaceous nodule of the left scalp (1.2 \u00d7\u20091.0 \u00d7\u20090.2 cm) that was a metastatic pancreatic adenosquamous carcinoma, representing a seemingly rare event. Two months prior, after complaining of right hip pain, an image revealed a right femoral lesion. A biopsy of that lesion showed moderately differentiated adenocarcinoma. Subsequent imaging showed a mass in the pancreatic tail and also markedly elevated serum tumor markers, CA 19\u20109 and carcinoembryonic antigen (5325 and 111.5 U\/mL, respectively). Before the appearance of the scalp nodule, the patient received radiotherapy and was started on chemotherapy, which was continued after diagnosis and resection of the nodule. Subsequent metastases developed in the liver, lung and additional cutaneous lesions. He died 11\u2009months after initial presentation with right hip pain. As this case shows, cutaneous metastases confer a poor prognosis, often with less than a year survival following their appearance.<\/jats:p>","DOI":"10.1111\/cup.13582","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T08:58:16Z","timestamp":1570352296000},"page":"263-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metastatic pancreatic adenosquamous carcinoma to the scalp: A case report and review of the literature"],"prefix":"10.1111","volume":"47","author":[{"given":"Behzad","family":"Salari","sequence":"first","affiliation":[{"name":"Lauren V. Ackerman Laboratory of Surgical Pathology, School of Medicine Washington University Medical Center  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Sheinbein","sequence":"additional","affiliation":[{"name":"Division of Dermatology, School of Medicine Washington University Medical Center  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5842-5691","authenticated-orcid":false,"given":"Ilana S.","family":"Rosman","sequence":"additional","affiliation":[{"name":"Lauren V. Ackerman Laboratory of Surgical Pathology, School of Medicine Washington University Medical Center  St. Louis Missouri"},{"name":"Division of Dermatology, School of Medicine Washington University Medical Center  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-5638","authenticated-orcid":false,"given":"Louis P.","family":"Dehner","sequence":"additional","affiliation":[{"name":"Lauren V. Ackerman Laboratory of Surgical Pathology, School of Medicine Washington University Medical Center  St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.06.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-019-04113-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.15"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.07.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.5.613"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02590.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31823069cf"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70173-Q"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.01.014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-007931"},{"issue":"2","key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF02825511","article-title":"Cutaneous metastases from pancreatic cancer","volume":"20","author":"Miyahara M","year":"1996","journal-title":"Int J Pancreatol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000240602.18688.43"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-201710001-01270"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201020"},{"issue":"2","key":"e_1_2_7_17_1","first-page":"410","article-title":"Two cases of pancreatic cancer associated with skin metastases","volume":"91","author":"Nakano S","year":"1996","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"e_1_2_7_18_1","first-page":"99","article-title":"Cutaneous metastases in pancreatic adenocarcinoma","volume":"38","author":"Puri AS","year":"1995","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.12.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2610"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25112"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-16-0436"},{"issue":"4","key":"e_1_2_7_23_1","first-page":"273","article-title":"Cutaneous metastasis of pancreatic adenocarcinoma after kidney transplant: a case report and review of the literature","volume":"8","author":"Pontinen T","year":"2010","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_7_24_1","article-title":"Molecular mechanism underlying lymphatic metastasis in pancreatic cancer","author":"Xiao Z","year":"2014","journal-title":"Biomed Res Int"},{"key":"e_1_2_7_25_1","volume-title":"Ductal Carcinoma. Neoplasms with Apocrine Differentiation","author":"Requena L","year":"1998"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880175"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181ad36ea"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90400-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v4.i7.176"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:12:10Z","timestamp":1694092330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/cup.13582"],"URL":"https:\/\/doi.org\/10.1111\/cup.13582","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"assertion":[{"value":"2019-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}