{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:07:33Z","timestamp":1753888053413,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The World Health Organization (WHO) classification of hematopoietic and lymphoid tumors identifies distinctive subtypes of peripheral T\u2010cell lymphoma (PTCL), and, additionally, some PTCLs involving mostly extranodal sites like the skin. The difficulty of classifying PTCLs according to the normal stages of T\u2010cell differentiation and the lack of definitive diagnostic markers for most of the subtypes make the diagnosis of these diseases challenging. PTCL cases which do not fit into any of the specifically defined entities are categorized as PTCL not otherwise specified (PTCL\u2010NOS). PTCLs\u2010NOS represent less than 2% of the total cases of T\u2010cell lymphoma involving the skin. This article illustrates a case of a PTCL\u2010NOS in which tumor cells have an activated cytotoxic TCR\u03b1\u03b2+CD3+CD4+CD56+ T\u2010cell phenotype and histopathologic features of subcutaneous panniculitis\u2010like T\u2010cell lymphoma, leading to a fatal outcome.<\/jats:p>","DOI":"10.1111\/cup.13590","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T07:43:31Z","timestamp":1570607011000},"page":"280-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Activated\u2010cytotoxic TCR\u03b1\u03b2+CD4+ peripheral T\u2010cell lymphoma with hypodermal localization: Case report of a lymphoproliferative disorder probably evolved from the CD4+ cytotoxic T\u2010cell subpopulation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-8242","authenticated-orcid":false,"given":"Dario M.","family":"Tomasini","sequence":"first","affiliation":[{"name":"Dermatological Service Hospital of Busto Arsizio, Azienda Socio Sanitaria della Valle Olona  Busto Arsizio Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Serio","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital of Busto Arsizio, Azienda Socio Sanitaria della Valle Olona  Busto Arsizio Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Landoni","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Busto Arsizio, Azienda Socio Sanitaria della Valle Olona  Busto Arsizio Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Appio","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Busto Arsizio, Azienda Socio Sanitaria della Valle Olona  Busto Arsizio Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Crivelli","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital of Busto Arsizio, Azienda Socio Sanitaria della Valle Olona  Busto Arsizio Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bregni","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital of Busto Arsizio, Azienda Socio Sanitaria della Valle Olona  Busto Arsizio Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"volume-title":"World Health Organization Classification of Tumours. 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