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We report an unusual case of a sclerotic lipoma diagnosed on the scalp of a 66\u2010year\u2010old female. The patient presented to the outpatient clinic with a 3\u2010 to 4\u2010year history of an enlarging and irritated 2.6\u2010cm nodule on the anterior crown of the scalp, clinically thought to be a pilar cyst. Histopathological examination from the excisional specimen revealed a well\u2010circumscribed dermal to subcutaneous tumor with ample sclerotic collagen bundles, an increased number of CD34 positive spindled cells, and prominent S\u2010100 positive mature adipocytes comprising greater than 50% of the tumor. We present this case given its atypical clinical and histopathological presentation, review the literature of sclerotic lipomas, and discuss the differential diagnosis to raise awareness of this rare entity.<\/jats:p>","DOI":"10.1111\/cup.13593","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T09:09:24Z","timestamp":1570871364000},"page":"286-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["There is fat in this sclerosis: A case report of sclerotic lipoma and review of the literature"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1985-8173","authenticated-orcid":false,"given":"Yan","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ata S.","family":"Moshiri","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Washington  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward F.","family":"Chan","sequence":"additional","affiliation":[{"name":"Dermatology Ltd.  Media Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trisha S.","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Dermatology Ltd.  Media Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Kozic","sequence":"additional","affiliation":[{"name":"Dermatology Ltd.  Media Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalie","family":"Elenitsas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuong V.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2015.16.2.99"},{"volume-title":"Andrews' Diseases of the Skin: Clinical Dermatology","year":"2005","author":"James WD","key":"e_1_2_6_3_1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-006-0189-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20975"},{"issue":"5","key":"e_1_2_6_6_1","first-page":"901","article-title":"Lipoma excision","volume":"65","author":"Salam GA","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200608000-00003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.2310836.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01995.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0242-6498(06)70668-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31827b65e3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01001.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10142"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000915"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPQEG6YNN6CNAL"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00421.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10195-009-0058-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000146014.22624.8e"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700230"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13593","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13593","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:12:05Z","timestamp":1694092325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/cup.13593"],"URL":"https:\/\/doi.org\/10.1111\/cup.13593","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"assertion":[{"value":"2019-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}