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We report a series of eight histopathologically distinct verrucous pilar cysts, distinguished from traditional verrucous epidermoid cysts by trichilemmal keratinization, as well as two verrucous hybrid pilar\u2010epidermoid cysts. These lesions contain characteristic stratified epithelial linings with abrupt transitions to compact eosinophilic keratin, as well as areas of papillomatosis, coarse intracytoplasmic keratohyalin granules, and vacuolar structures suggestive of HPV\u2010induced cytopathic change. HPV\u201024, a \u03b2 genus HPV species, was identified by degenerate polymerase chain reaction in DNA extracted from two of the lesions, and the presence of \u03b2\u2010HPV E4 protein was confirmed by immunohistochemistry. HPV\u201060, the HPV species most commonly reported in verrucous epidermoid cysts, was not detected. Verrucous pilar cysts represent histopathologically and potentially etiologically distinct lesions which may be underrecognized.<\/jats:p>","DOI":"10.1111\/cup.13599","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T16:12:06Z","timestamp":1571415126000},"page":"381-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Verrucous pilar cysts infected with beta human papillomavirus"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9686-1611","authenticated-orcid":false,"given":"Benjamin A.","family":"Nanes","sequence":"first","affiliation":[{"name":"Department of Dermatology UT Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soolmaz","family":"Laknezhad","sequence":"additional","affiliation":[{"name":"Department of Dermatology UT Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5729-3532","authenticated-orcid":false,"given":"Bahir","family":"Chamseddin","sequence":"additional","affiliation":[{"name":"Department of Dermatology UT Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Doorbar","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Cambridge  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Mir","sequence":"additional","affiliation":[{"name":"Dermpath Diagnostics Port Chester  New York"},{"name":"New York Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-0565","authenticated-orcid":false,"given":"Gregory A.","family":"Hosler","sequence":"additional","affiliation":[{"name":"Department of Dermatology UT Southwestern Medical Center  Dallas Texas"},{"name":"ProPath, Dallas  Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology UT Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.04520010056007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200306000-00009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-9-2437"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01645.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670360063010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70201-P"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb00240.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-013-1727-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81950-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1994.tb03273.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb08707.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02135.x"},{"issue":"3","key":"e_1_2_6_14_1","first-page":"254","article-title":"Human papillomavirus type 59 identified in a verrucous cyst of the flank","volume":"16","author":"Kim H","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071792"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14089"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2010.05.011"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199202000-00006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb00663.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13156"},{"issue":"2","key":"e_1_2_6_21_1","first-page":"169","article-title":"Epidermodysplasia verruciformis. 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