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However, results obtained by individual research groups differ in terms of detection frequency and level of this protein, as well as localization of stained cells within tumor. Possible reasons for the discrepancies are analyzed in this review: the application of different antibodies, the use of standard histopathological sections or tissue microarrays and the analyzes of staining results based on different algorithms. COX\u20102 level is significantly lower in nevi than in melanomas, increases gradually with progression of these malignant cancers and reaches the highest values in metastases. These gradual changes in COX\u20102 expression appear to be difficult to analyze based only on subjective assessment of staining intensity. The most convergent data were obtained using antibodies for N\u2010terminal fragments of COX\u20102 protein and analyzing results based on calculation of percentage fraction of positive cells. The extent of stained area in specimen thus appears to be more important than the intensity of staining in terms of evaluation of COX\u20102 performance as a diagnostic and prognostic marker of cutaneous melanoma.<\/jats:p>","DOI":"10.1111\/cup.13606","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T14:30:04Z","timestamp":1572618604000},"page":"363-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunohistochemical detectability of cyclooxygenase\u20102 expression in cells of human melanocytic skin lesions: A methodological review"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6121-4465","authenticated-orcid":false,"given":"\u0141ukasz","family":"Ku\u017abicki","sequence":"first","affiliation":[{"name":"Department of Human Biology Institute of Biology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in 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