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Previous reports have found success with sunitinib in imatinib\u2010resistant GIST, but we report a certain wild\u2010type <jats:italic>KIT<\/jats:italic> mutation GIST with cutaneous and subcutaneous metastasis that was unresponsive to multiple tyrosine kinase inhibitor (TKI) treatments. This case illustrates that knowing the specific type of <jats:italic>KIT<\/jats:italic> mutations may uncover resistance of certain GIST's to TKIs, necessitating more targeted and alternative therapy.<\/jats:p>","DOI":"10.1111\/cup.13611","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T18:59:20Z","timestamp":1573239560000},"page":"398-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multidrug resistant gastrointestinal stromal tumor with multiple metastases to the skin and subcutaneous soft tissue: A case report and review of literature"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9462","authenticated-orcid":false,"given":"Divya J.","family":"Aickara","sequence":"first","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine University of Miami  Coral Gables Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"McBride","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine University of Miami  Coral Gables Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Morrison","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine University of Miami  Coral Gables Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. 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