{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:05:33Z","timestamp":1762999533189,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chlorpromazine may induce abnormal skin hyperpigmentation in exposed areas, described as slate\u2010gray, purple, or blue\u2010grayish discoloration. A 58\u2010year\u2010old man with schizophrenia, had been taking chlorpromazine for 5\u2009years, and his sun\u2010exposed skin areas exhibited a blue\u2010grayish color. Large deposits of brown pigment and granular basophilic material were seen in the dermis with light microscopy. HMB\u201045 and anti\u2010Melan\u2010A antibody immunostaining labeled some pigment in the dermis. Transmission electron microscopy identified deposits among dermal collagen bundles collagen in both transverse and longitudinal sections. In the latter, an arboriform aspect of deposits was quite clear, and some melanophages were also seen. The three\u2010dimensional examination of the dermis with scanning electron microscopy also identified deposits, which at higher magnification demonstrated an appearance in the shape of leaves, grass\u2010like, interspersed with normal collagen. These results suggest a complex pathogenic mechanism, including deposition of dermal melanin together with drug itself and potentially additional unknown metabolites.<\/jats:p>","DOI":"10.1111\/cup.13612","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T16:56:11Z","timestamp":1573577771000},"page":"402-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Light and electron microscopy of chlorpromazine\u2010induced hyperpigmentation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-1831","authenticated-orcid":false,"given":"Talita","family":"Calheiros","sequence":"first","affiliation":[{"name":"Post\u2010Graduation Program in Health Catholic University of Pelotas  Pelotas 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