{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:15:35Z","timestamp":1791562535250,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aplasia cutis congenita (ACC) is a rare and heterogeneous disorder characterized by congenital absence of skin. The scalp is the most commonly affected site and lesions may overlie deeper ectodermal abnormalities. The exact etiology is still unknown, and histopathologic features are poorly defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A series of 10 cases from nine patients was analyzed to characterize the clinicopathologic spectrum and age\u2010related changes of ACC of the scalp. Hematoxylin and eosin, S100, Elastica van Gieson, and Weigert elastic stains were performed, and clinical information was retrieved from archived medical files.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient ages ranged from 1\u2009day to 39\u2009years (median 57 months). All cases resembled deep\u2010reaching scars with almost complete loss of all adnexal structures. Isolated residual hair follicles were present in 8\/10 and sweat glands and ducts in 2\/10 cases. The subcutis was thinned or absent. Elastic fibers were always more fragmented than in normal tissue, and the thickness and density increased over time. There was no gain of adnexal structures with increasing age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ACC represents a congenital scarring alopecia with permanent loss of skin appendages. Histopathologic changes resemble a deep\u2010reaching scar with fragmented elastic fibers and differentiate ACC from all other forms of non\u2010traumatic congenital alopecias.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13644","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T10:30:56Z","timestamp":1578306656000},"page":"439-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aplasia cutis congenita of the scalp: Histopathologic features and clinicopathologic correlation in a case series"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-3601","authenticated-orcid":false,"given":"Maximilian","family":"Gassenmaier","sequence":"first","affiliation":[{"name":"Department of Dermatology Eberhard Karls University of T\u00fcbingen  T\u00fcbingen 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