{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:08:47Z","timestamp":1759529327912,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transforming growth factor\u2010beta1 (TGF\u2010\u03b21) is expressed in normal epidermis. TGF\u2010\u03b21 potently inhibits keratinocyte proliferation and immunomodulatory properties, mainly by suppressing immune responses to self\u2010antigens. Lichen planus (LP) is a form of dermatitis caused by cell\u2010mediated immune dysfunction, but the exact pathogenic pathways are unknown, which poses therapeutic challenges. We report on a 68\u2010year\u2010old man who developed multiple pruritic, discrete, and well\u2010demarcated, flat\u2010topped red\u2010purple papules and macules on the back and upper arms following 4 cycles of treatment with TGF\u2010\u03b2 receptor I (TGFBR\u2010I) inhibitor, ly3200882, for metastatic chondrosarcoma. The biopsy showed hyperkeratosis, wedge\u2010shaped hypergranulosis, elongation of the rete ridges, and a dense band\u2010like lymphohistiocytic infiltrate admixed with colloid bodies and pigment incontinence, consistent with LP. Temporal correlation suggested that the TGFBR\u2010I inhibitor might be a trigger. Treatment with topical clobetasol and oral metronidazole led to partial resolution of the lesions with postinflammatory hyperpigmentation. We believe this is the first reported case of LP related to TGFBR\u2010I inhibitor therapy. This report expands the list of cutaneous adverse events associated with this novel class of targeted therapy. More importantly, this report supports emerging evidence that failure of TGF\u2010\u03b21 activation\/signal transduction is an important mechanism in the pathogenesis of LP and suggests the TGF\u2010\u03b21 pathway as a potential therapeutic target in this disease.<\/jats:p>","DOI":"10.1111\/cup.13645","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T01:55:28Z","timestamp":1578880528000},"page":"490-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lichen planus related to transforming growth factor beta inhibitor in a patient with metastatic chondrosarcoma: a case report"],"prefix":"10.1111","volume":"47","author":[{"given":"Maya","family":"Farah","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly 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