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Additionally, melanoma risk is increased in mixed cancer syndromes caused by mutations in\n                    <jats:italic>PTEN<\/jats:italic>\n                    ,\n                    <jats:italic>BRCA2<\/jats:italic>\n                    ,\n                    <jats:italic>BRCA1<\/jats:italic>\n                    ,\n                    <jats:italic>RB1<\/jats:italic>\n                    , and\n                    <jats:italic>TP53<\/jats:italic>\n                    . While early onset, multiple tumors, and family cancer history remain the most valuable clinical clues for hereditary melanoma, characteristic epithelioid cytology of melanocytic tumors may suggest an underlying\n                    <jats:italic>BAP1<\/jats:italic>\n                    mutation. Herein, we review the clinical and histopathologic characteristics of melanocytic tumors associated with these germline mutations and discuss the role of genetic counseling.\n                  <\/jats:p>","DOI":"10.1111\/cup.13689","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T06:55:21Z","timestamp":1586156121000},"page":"606-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Germline mutations predisposing to melanoma"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-3418","authenticated-orcid":false,"given":"Atrin","family":"Toussi","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California, Davis  Sacramento California 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