{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:39:28Z","timestamp":1778755168801,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Located on chromosome locus 5p15.33, telomerase reverse transcriptase (<jats:italic>TERT<\/jats:italic> or h<jats:italic>TERT<\/jats:italic>) encodes the catalytic subunit of telomerase which permits lengthening and preservation of telomeres following mitosis. Mutations in <jats:italic>TERT<\/jats:italic> promoter (<jats:italic>TERT<\/jats:italic>\u2010p) upregulate expression of <jats:italic>TERT<\/jats:italic>, allowing survival of malignant cells and tumor progression in wide variety of malignancies including melanoma. The objective of this review is to examine the roles of <jats:italic>TERT<\/jats:italic> and <jats:italic>TERT\u2010p<\/jats:italic> in the pathogenesis, diagnosis, and prognostication of cutaneous melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All studies of <jats:italic>TERT<\/jats:italic> or <jats:italic>TERT\u2010p<\/jats:italic> in cutaneous melanocytic neoplasms with the following inclusion criteria were reviewed: publication date between 2010 and 2019, English language, and series of \u22653 cases were reviewed for evidence supporting the role of <jats:italic>TERT<\/jats:italic> in pathogenesis, diagnosis, and prognosis. Studies with &lt;3 cases or focused primarily on mucosal or uveal melanocytic tumors were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusion<\/jats:title><jats:p><jats:italic>TERT<\/jats:italic>\u2010p mutations are frequent in chronic and non\u2010chronic sun damage melanoma and correlate with adverse prognosis, inform pathogenesis, and may provide diagnostic support. While <jats:italic>TERT<\/jats:italic>\u2010p mutations are uncommon in acral melanoma, <jats:italic>TERT<\/jats:italic> copy number gains and gene amplification predict reduced survival. Among atypical spitzoid neoplasms, <jats:italic>TERT<\/jats:italic>\u2010p mutations identify biologically aggressive tumors and support the diagnosis of spitzoid melanoma. <jats:italic>TERT<\/jats:italic>\u2010p methylation may have prognostic value in pediatric conventional melanoma and drive tumorigenesis in melanoma arising within congenital nevi. Finally, <jats:italic>TERT<\/jats:italic>\u2010p mutations may aid in the differentiation of recurrent nevi from recurrent melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13691","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T14:02:04Z","timestamp":1584972124000},"page":"710-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<scp><i>TERT<\/i><\/scp> and <scp><i>TERT<\/i><\/scp> promoter in melanocytic neoplasms: Current concepts in pathogenesis, diagnosis, and prognosis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-0826","authenticated-orcid":false,"given":"Kiran","family":"Motaparthi","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Florida College of Medicine  Gainesville 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