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We herein report a case of the SR of intralymphatic cutaneous metastases of a breast carcinoma with spontaneously\u2010induced T\u2010cell\u2010mediated cytotoxic response. An 86\u2010year\u2010old female was diagnosed with locally advanced right breast carcinoma and axillary lymph node metastases, without distant metastases The patient refused any therapy. Six months afterwards, she developed multiple, asymptomatic purpura\u2010like plaques with prominent teleangectasias on her right chest wall, continuous to the previous surgical scar and on her ipsilateral abdomen. Skin biopsy showed aggregates of atypical cells admixed with erythrocyte thrombi within dilated dermal lymphatic vessels. SR of the cutaneous lesions occurred within 6\u2009months and persisted at the 15\u2009months follow\u2010up in the absence of therapy, whilst no signs of internal relapse were observed. Immunohistochemically, the estrogen\u2010negative, CK7\u2010positive, C\u2010erb B2\u2010positive intralymphatic metastases were associated with extensive infiltration of CD8\u2010positive cytototoxic T lymphocytes. Factors that may have precluded the implantation of intralymphatic metastases leading to SR are discussed, with local immune surveillance being one major hypothesis.<\/jats:p>","DOI":"10.1111\/cup.13694","type":"journal-article","created":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T06:54:08Z","timestamp":1585464848000},"page":"758-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cytotoxic\u2010mediated spontaneous regression of inflammatory cutaneous metastases of breast carcinoma"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-2511","authenticated-orcid":false,"given":"Carlo","family":"Tomasini","sequence":"first","affiliation":[{"name":"IRCCS Fondazione Policlinico San Matteo, Department of Medical\u2010Surgical, Diagnostic and Pediatric Sciences, Dermatologic Clinic University of Pavia School of Medicine  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195609000-00007"},{"issue":"11","key":"e_1_2_4_3_1","first-page":"5","article-title":"Spontaneous regression of cancer and the importance of finding its cause","volume":"44","author":"Cole WH","year":"1976","journal-title":"Natl Cancer Inst Monogr"},{"issue":"6","key":"e_1_2_4_4_1","first-page":"571","article-title":"Spontaneous regression of cancer: possible mechanisms","volume":"12","author":"Papac RJ","year":"1998","journal-title":"In Vivo"},{"issue":"1","key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jons.2016.04.008","article-title":"Spontaneous tumor regression","volume":"2","author":"Salman T","year":"2016","journal-title":"J Oncol Sci"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869009090048"},{"issue":"26","key":"e_1_2_4_7_1","first-page":"4001","article-title":"Spontaneous remission of breast cancer. 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