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We report an exceptional case of Bowen disease exhibiting multiple foci of matrical differentiation, as confirmed by means of immunohistochemical studies. Several types of divergent, non\u2010squamous differentiation have been exceptionally reported in cutaneous squamous cell carcinoma in situ (cSCCIS), including sebaceous, mucinous\/glandular, poroid, tricholemmal, and neuroendocrine differentiation; matrical differentiation may be added to this list. Our findings further emphasize the undifferentiated nature of neoplastic cells in cSCCIS.<\/jats:p>","DOI":"10.1111\/cup.13714","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T06:23:02Z","timestamp":1587104582000},"page":"840-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bowen disease with matrical differentiation: Report of an exceptional histopathologic presentation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-441X","authenticated-orcid":false,"given":"Andrea","family":"Saggini","sequence":"first","affiliation":[{"name":"Dermatopathology Bodensee  Friedrichshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Bang","sequence":"additional","affiliation":[{"name":"S\u00fcdharz Klinikum Nordhausen  Nordhausen 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