{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:39:31Z","timestamp":1785368371577,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The immune checkpoint molecule PD\u2010L1 represents an important target in oncological immune therapy. The aim of our study was to evaluate PD\u2010L1 expression and the composition of the tumor microenvironment (TME) in Kaposi sarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemical stains were performed for PD\u2010L1, CD3, CD33, CD68, and CD168 in 24 Kaposi sarcoma samples. In PD\u2010L1\u2010positive cases, the double stains for PD\u2010L1, CD31, podoplanin, and HHV8 were added.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PD\u2010L1 was observed in 71% of the samples and was predominantly located in the TME. PD\u2010L1 expression was significantly higher in nodular stage than in patch\/plaque stage. The TME consisted of CD68+\/CD163+ macrophages, CD33+ myloid\u2010derived suppressor cells and monocytes and CD3+ T\u2010cells. The TME showed a peritumoral distribution in nodular stage, in contrast to a diffuse distribution in patch\/plaque stage. In 12 samples (50%), no plasma cells were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In nodular stage of KS, the TME is pushed back in the periphery of the tumor nodules. The PD\u2010L1\u2010positive TME between the tumor cells might protect them from the immune attack. An anti\u2010PD\u2010L1 treatment might be promising in KS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13716","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T12:34:22Z","timestamp":1587386062000},"page":"888-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Stage\u2010related <scp>PD\u2010L1<\/scp> expression in Kaposi sarcoma tumor microenvironment"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-337X","authenticated-orcid":false,"given":"Beatrice","family":"Joest","sequence":"first","affiliation":[{"name":"Department of Dermatology HELIOS\u2010Klinikum Hildesheim  Hildesheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Kempf","sequence":"additional","affiliation":[{"name":"Kempf und Pfaltz Histologische Diagnostik  Z\u00fcrich Switzerland"},{"name":"Department of Dermatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbeneshe","family":"Berisha","sequence":"additional","affiliation":[{"name":"Kempf und Pfaltz Histologische Diagnostik  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Peyk","sequence":"additional","affiliation":[{"name":"Department of Consultation\u2010Liaison\u2010Psychiatry and Psychosomatic Medicine University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tronnier","sequence":"additional","affiliation":[{"name":"Department of Dermatology HELIOS\u2010Klinikum Hildesheim  Hildesheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mitteldorf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"119","article-title":"Kaposi's sarcoma: a model of both malignancy and chronic inflammation","volume":"49","author":"Douglas JL","year":"2007","journal-title":"Panminerva Med"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"40","article-title":"Immunological and inflammatory features of Kaposi's sarcoma and other Kaposi's sarcoma\u2010associated herpesvirus\/human herpesvirus 8\u2010associated neoplasias","volume":"12","author":"Riva G","year":"2010","journal-title":"AIDS Rev"},{"key":"e_1_2_7_4_1","first-page":"341","volume-title":"WHO Classification of Skin Tumours","author":"Grayson W","year":"2018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07784-9_35"},{"key":"e_1_2_7_6_1","first-page":"264","volume-title":"Dermatopathologie","author":"Kempf W","year":"2007"},{"key":"e_1_2_7_7_1","first-page":"1021","volume-title":"Skin Pathology","author":"Weedon D","year":"2002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2017.1356509"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.217"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.36"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090331"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.7.1027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.64"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0034"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000851"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5118"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12973"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200690"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200694"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.130"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-016-0807-z"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2019.07.024"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0855"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1304337"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15543"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000317"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001287"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00917-17"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2007.08.021"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2012.673191"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.02.003"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-015-1765-6"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4179-z"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13716","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T15:35:02Z","timestamp":1693928102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,29]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/cup.13716"],"URL":"https:\/\/doi.org\/10.1111\/cup.13716","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,29]]},"assertion":[{"value":"2019-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}