{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:11:58Z","timestamp":1783609918914,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aneurysmal fibrous histiocytoma is an uncommon variant of cutaneous fibrous histiocytomas with a local recurrence rate of 19%. We present a case of aneurysmal fibrous histiocytoma in a 20\u2010year\u2010old female with a regional lymph node metastasis and subsequent satellite nodule. The patient initially presented with a 1\u2010month history of two palpable nodules in left lower anterior shoulder and left axilla. Needle core biopsies from both lesions revealed an atypical spindle cell neoplasm with a differential diagnosis of aneurysmal fibrous histiocytoma and angiomatoid fibrous histiocytoma. The axillary dissection confirmed a metastatic deposit in 1 out of 22 lymph nodes. At 6\u2009months a satellite nodule arose between the resection scar and the axilla histopathologically demonstrating a cellular spindle cell nodule at the dermis subcutaneous junction with large, blood\u2010filled pseudovascular spaces lined by histiocytes. The periphery of the lesion showed collagen trapping without a lymphoplasmacytic infiltrate. The lesional cells were diffusely positive for CD10 and focally for CD68 and Illumina RNA fusion panel sequencing was negative. Herein we present this case of metastatic aneurysmal fibrous histiocytoma with review of the literature and discussion of biology, cytogenetic alterations, and differential diagnosis.<\/jats:p>","DOI":"10.1111\/cup.13738","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T07:44:31Z","timestamp":1589269471000},"page":"870-875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Metastatic aneurysmal fibrous histiocytoma in a 20\u2010year\u2010old woman: A rare case report with review of the literature and discussion of its genomic features"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-5116","authenticated-orcid":false,"given":"Kimberly A.","family":"Wood","sequence":"first","affiliation":[{"name":"University Health Network, Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Easson","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Princess Margaret Cancer Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Ghazarian","sequence":"additional","affiliation":[{"name":"University Health Network, Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Saeed Kamil","sequence":"additional","affiliation":[{"name":"University Health Network, Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"McKee's Pathology of the Skin with Clinical Correlations","author":"Calonje E","year":"1759"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810415)47:8<2053::AID-CNCR2820470825>3.0.CO;2-A"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00193.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31827070d4"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880115"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.157"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199407000-00002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200201000-00004"},{"key":"e_1_2_5_10_1","first-page":"204","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","author":"Antonescu CR","year":"2013"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2147::AID-CNCR2820440627>3.0.CO;2-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199012000-00004"},{"issue":"4","key":"e_1_2_5_13_1","first-page":"479","article-title":"Angiomatoid malignant fibrous histiocytoma: Cytologic, immunohistochemical, ultrastructural, and flow cytometric study of 20 cases","volume":"3","author":"Pettinato G","year":"1990","journal-title":"Mod Pathol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90233-F"},{"issue":"11","key":"e_1_2_5_15_1","first-page":"1065","article-title":"Angiomatoid features in fibrohistiocytic sarcomas. 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