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Small case series have suggested differences between psES and Ewing sarcoma (ES) of bone or deep soft tissues: psES appears to have a more indolent course and a higher 5\u2010year overall survival rate. PsES is more common in older adolescent females as opposed to younger males in their peak growth velocity years in bone or deep soft tissue ES. We present a case report of a 17\u2010year\u2010old female with a relatively static nodule on her left thigh for 4\u2009years. Morphologic, immunohistochemical, and molecular evaluations confirmed ES. Patient underwent a gross\u2010total resection and a shortened course of adjuvant chemotherapy without radiation. Cancer gene panel testing found three gene abnormalities (in addition to <jats:italic>EWSR1\u2010FLI1<\/jats:italic> fusion): <jats:italic>CCND1<\/jats:italic> copy number gain, <jats:italic>ELF3<\/jats:italic> copy number loss, and <jats:italic>TNFRSF14<\/jats:italic> copy number loss. To our knowledge, this is the first published case report of psES to include genomic sequencing and the first to report <jats:italic>ELF3<\/jats:italic> and <jats:italic>TNFRSF14<\/jats:italic> abnormalities in ES. Larger series of psES cases with genomic profiling are needed to elucidate a possible genetic etiology for its more indolent clinical course and favorable outcomes.<\/jats:p>","DOI":"10.1111\/cup.13762","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T06:17:15Z","timestamp":1591078635000},"page":"970-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary superficial Ewing sarcoma: A unique entity? A case report including novel findings of <scp><i>ELF3<\/i><\/scp> and <scp><i>TNFRSF14<\/i><\/scp> copy number loss"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-4600","authenticated-orcid":false,"given":"Linda D.","family":"Murphy","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hematology\/Oncology Section, Department Laboratory Medicine, Department of Radiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"},{"name":"Department of Pediatrics, Hematology\/Oncology Section \u2010 Douglass Arkansas Children's Hospital  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gray M.","family":"Orman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology\/Oncology Section, Department Laboratory Medicine, Department of Radiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia A.","family":"Bridge","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology The Translational Genomics Research Institute (TGen)\/Ashion Analytics  Phoenix Arizona USA"},{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitanjali","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerad M.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology\/Oncology Section, Department Laboratory Medicine, Department of Radiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Douglass","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology\/Oncology Section, Department Laboratory Medicine, Department of Radiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"},{"name":"Department of Pediatrics, Hematology\/Oncology Section University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21219"},{"key":"e_1_2_4_3_1","first-page":"1984","volume-title":"Nathan and Oski's Hematology and Oncology of Infancy and Childhood","author":"Orkin SHFD","year":"2015"},{"key":"e_1_2_4_4_1","first-page":"860","volume-title":"Principles and Practice of Pediatric Oncology","author":"Pizzo 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