{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T04:25:42Z","timestamp":1751689542757,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) is primarily a disease of older adults and is occasionally an incidental finding on skin biopsies accompanying epithelial neoplasms and insect bite reactions. In rare instances, however, it produces leukemic infiltrates showing clinical and histopathologic overlap with primary cutaneous B\u2010cell lymphomas including primary cutaneous marginal zone lymphoma (PCMZL). Even less frequently, such findings serve as the initial disease manifestation. We present an exceptional case of a 61\u2010year\u2010old man with no past medical history whose clinical and histopathologic findings raised consideration for PCMZL with abnormal B\u2010cells colonizing germinal center follicles; however, faint CD5 and CD23 co\u2010expression raised the differential diagnosis of CLL\/SLL. In light of an ambiguous clinical presentation with widely distributed papules and plaques, peripheral blood flow cytometry was also performed, revealing high count of CLL\u2010type monoclonal B lymphocytosis. Subsequent workup revealed bone marrow involvement and mesenteric lymphadenopathy, supporting the diagnosis of SLL. Follicular colonization by SLL has not been previously reported. Our case underscores the importance of subtle immunophenotypic clues and correlations with clinical and radiologic findings in the workup of B\u2010cell lymphomas presenting in the skin.<\/jats:p>","DOI":"10.1111\/cup.13765","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T13:34:34Z","timestamp":1591536874000},"page":"72-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Small lymphocytic lymphoma mimicking primary cutaneous marginal zone lymphoma with colonization of germinal center follicles"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-0381","authenticated-orcid":false,"given":"Robert E.","family":"LeBlanc","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"},{"name":"Audrey and Theodor Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joi B.","family":"Carter","sequence":"additional","affiliation":[{"name":"Audrey and Theodor Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"},{"name":"Section of Dermatology, Department of Surgery Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhjot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"},{"name":"Audrey and Theodor Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Lansigan","sequence":"additional","affiliation":[{"name":"Audrey and Theodor Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"},{"name":"Section of Hematology\/Oncology, Department of Medicine, Dartmouth\u2010Hitchcock Medical Center; 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