{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:16:18Z","timestamp":1792304178073,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant tumor of the vulva is the fourth gynecological malignancy in frequency. Close to 70% of all vulvar malignancies are related to high\u2010risk human papillomavirus (HPV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search for non\u2010HPV\u2010related malignant tumors of the vulva was performed in the last 20\u2009years (2000\u20102020) in the pathology database of a single tertiary institution. We aim to estimate the prevalence of non\u2010HPV\u2010related malignancies in our population, describe clinicopathological features of these tumors and investigate the expression of some potential therapeutic targets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 71 patients were recovered; 26 patients (36%) had the diagnosis of extramammary Paget disease, 17 patients (24%) had basal cell carcinomas, 17 patients (24%) had primary melanomas, 10 patients (14%) had metastatic disease to the vulva and one patient (1%) had a primary dermatofibrosarcoma protuberans. Fifty\u2010four percent of patients with extramammary Paget disease had a secondary malignancy and 12.5% had invasive disease. Programmed death\u2010ligand 1 (PDL\u20101) was positive in seven out of nine primary melanomas and Her2\/neu was overexpressed in six out of seven extramammary Paget disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010HPV\u2010related malignancies are important differential diagnoses in patient with vulvar lesions. Additional research is necessary to further understand these complex malignancies and potential new therapeutic targets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13768","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T17:13:42Z","timestamp":1591636422000},"page":"917-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Non\u2010human\u2010papillomavirus\u2010related malignancies of the vulva: A clinicopathological study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6383-2240","authenticated-orcid":false,"given":"Karina","family":"Furlan","sequence":"first","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prih","family":"Rohra","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical 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