{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:32:44Z","timestamp":1787884364403,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous carcinosarcomas are rare biphenotypic tumors that simultaneously show epithelial and mesenchymal differentiation. The most common carcinomatous components in skin carcinosarcomas are basal cell carcinoma and squamous cell carcinoma; adnexal carcinomas are rarely encountered. We report a case of an adnexal carcinoma with ductal and squamous differentiation and spindle cell component, which is interpreted as carcinosarcoma. Loss of immunohistochemical expression of E\u2010cadherin and \u03b2\u2010catenin detected in the sarcomatous component suggested epithelial mesenchymal transition (EMT). RNA sequencing analysis identified several gene mutations and alterations such as translocations and upregulations\/downregulations, either shared by the two components of the tumor or differentially present in the carcinoma or the sarcoma parts. Thus, mutations in genes, such as <jats:italic>TP53<\/jats:italic>, were found in both components of the tumor while mutations in <jats:italic>PDGFRA<\/jats:italic> and <jats:italic>RB1<\/jats:italic> (a pathogenic missense mutation) were exclusively present in the sarcomatous areas, further supporting EMT. EMT is a dynamic process by which tumors acquire mesenchymal phenotype while simultaneously losing epithelial properties. Although the pathways involved in EMT have been extensively studied, this phenomenon still needs to be investigated in cutaneous tumors of adnexal origin for a better understanding of their pathogenesis. These molecular changes may represent promising targets for personalized therapies.<\/jats:p>","DOI":"10.1111\/cup.13782","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T10:24:20Z","timestamp":1592735060000},"page":"526-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cutaneous adnexal carcinosarcoma: Immunohistochemical and molecular evidence of epithelial mesenchymal transition"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-9175","authenticated-orcid":false,"given":"DongHyang","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira","family":"Ronen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-0662","authenticated-orcid":false,"given":"Alessio","family":"Giubellino","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Keiser","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-0573","authenticated-orcid":false,"given":"Phyu P.","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5346-2669","authenticated-orcid":false,"given":"Priyadharsini","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7899-4138","authenticated-orcid":false,"given":"Michael T.","family":"Tetzlaff","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4703-7009","authenticated-orcid":false,"given":"Doina","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-6222","authenticated-orcid":false,"given":"Jonathan L.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7422-0661","authenticated-orcid":false,"given":"Carlos A.","family":"Torres\u2010Cabala","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"VirchowR. Die krankhaften Geschwiste Berlin Hirschwald 2: 65 104 1864\u20131865. 18. Cornil and Ranvier quoted by Strassberg."},{"issue":"4","key":"e_1_2_7_3_1","first-page":"243","article-title":"Carcinosarcoma of the skin","volume":"17","author":"Dawson EK","year":"1972","journal-title":"J R Coll Surg Edinb"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12843"},{"issue":"6","key":"e_1_2_7_5_1","first-page":"673","article-title":"Carcinosarcomas: tumors in transition?","volume":"30","author":"Somarelli JA","year":"2015","journal-title":"Histol Histopathol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00260.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2005.12.057"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12593-010-0013-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.5.321"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.07.014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-020-0925-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24803"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2004.05811.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5457"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11070964"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1628-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1718-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.01.006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.07.027"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071777"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199112000-00017"},{"issue":"4","key":"e_1_2_7_24_1","first-page":"4185","article-title":"Long non\u2010coding RNA Plasmacytoma variant translocation 1 (PVT1) enhances proliferation, migration, and epithelial\u2010mesenchymal transition (EMT) of pituitary adenoma cells by activating beta\u2010catenin, c\u2010Myc, and cyclin D1 expression","volume":"18","author":"Zhang Y","year":"2019","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533034617700559"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5026"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-011-9505-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.01.029"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.12.67"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-018-0059-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2019.03.005"},{"issue":"2","key":"e_1_2_7_32_1","first-page":"388","article-title":"Malignant transformation of eccrine spiradenoma","volume":"11","author":"Dabska M","year":"1972","journal-title":"Pol Med J"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1979.tb01139.x"},{"issue":"3","key":"e_1_2_7_34_1","first-page":"265","article-title":"The potential malignancy of eccrine spiradenoma","volume":"19","author":"Meriggi F","year":"1989","journal-title":"Ital J Surg Sci"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199008000-00002"},{"issue":"6","key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2340\/0001555573444446","article-title":"Malignant aneuploid spindle\u2010cell transformation in a proliferating trichilemmal tumour","volume":"73","author":"Alvarez\u2010Qui\u00f1ones M","year":"1993","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"e_1_2_7_37_1","first-page":"168","article-title":"Carcinosarcoma arising in eccrine spiradenoma. a morphologic and immunohistochemical study","volume":"14","author":"Huerre M","year":"1994","journal-title":"Ann Pathol"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199404000-00018"},{"issue":"5","key":"e_1_2_7_39_1","first-page":"501","article-title":"Carcinosarcoma arising in eccrine spiradenoma of the breast. report of a case and review of the literature","volume":"120","author":"Saboorian MH","year":"1996","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1996.tb03563.x"},{"issue":"2","key":"e_1_2_7_41_1","first-page":"189","article-title":"Case report and literature review: Primary cutaneous carcinosarcoma","volume":"35","author":"Ram R","year":"2005","journal-title":"Ann Clin Lab Sci"},{"issue":"1","key":"e_1_2_7_42_1","first-page":"67","article-title":"Malignant eccrine spiradenoma: A case report and review of the literature","volume":"27","author":"Ishikawa M","year":"2001","journal-title":"Dermatol Surg"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290810.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:05:17Z","timestamp":1693580717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/cup.13782"],"URL":"https:\/\/doi.org\/10.1111\/cup.13782","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,14]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}