{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:00:23Z","timestamp":1760014823074,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATLL) is a lymphoproliferative disorder of mature CD4\u2010positive T\u2010cell lymphoid cells associated with retrovirus human T\u2010lymphotropic virus type\u20101 (HTLV\u20101) with a wide clinical and pathologic spectrum. We report a case of a 53\u2010year\u2010old African man who presented with fever and skin eruptions on the trunk composed of non\u2010itchy erythematous reticulated macules and papules initially suspected for viral exanthem or drug rash. Skin punch biopsy showed a dermal T\u2010cell lymphoid infiltrate with epidermotropism. The patient developed generalized lymphadenopathy and his peripheral blood showed lymphocytosis with atypical lymphocytes with convoluted nuclei. Our initial diagnosis was mycosis fungoides with S\u00e9zary syndrome. However, some clinical and histopathologic features were unusual. The acute onset, lack of previous skin lesions, the histomorphologic features of the dermal, nodal and peripheral blood lymphocytes and the geographic origin of the patient raised the suspicion of other T\u2010cell lymphomas, particularly ATLL. This was confirmed by a positive anti\u2010HTLV\u20101 serology. Our final diagnosis was acute variant ATLL. Different T\u2010cell lymphomas can involve the skin with overlapping clinical, histomorphologic and immunohistochemical features. Some clinical and pathologic features should alarm dermatologists and pathologists to the possibility of ATLL particularly in patients from HTLV\u20101 endemic geographic areas.<\/jats:p>","DOI":"10.1111\/cup.13789","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T11:32:50Z","timestamp":1608809570000},"page":"1103-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adult T\u2010cell leukemia\/lymphoma clinically confused with viral\/drug skin eruptions and pathologically misinterpreted as mycosis fungoides\/S\u00e9zary syndrome"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-1214","authenticated-orcid":false,"given":"Badr","family":"AbdullGaffar","sequence":"first","affiliation":[{"name":"Pathology section, Rashid hospital  Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suad","family":"Abdulrahman","sequence":"additional","affiliation":[{"name":"Pathology section, Rashid hospital  Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"first-page":"1411","volume-title":"Pathology of the Skin with Clinical Correlations","author":"McKee PH","key":"e_1_2_2_2_1"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0379-RS"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12328"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03526.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13337"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12599"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.10.006"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.12.006"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.07.049"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0037-3"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/KWJYBCCGTB90B6AE"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13789","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:42:58Z","timestamp":1692848578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,22]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/cup.13789"],"URL":"https:\/\/doi.org\/10.1111\/cup.13789","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2020,12,22]]},"assertion":[{"value":"2020-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}