{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:00:28Z","timestamp":1770231628491,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Histopathologically, scars can mimic superficial fibromatoses. Superficial fibromatoses are known to show nuclear \u03b2\u2010catenin immunoexpression, although the tumor types do not harbor <jats:italic>CTNNB1<\/jats:italic> or <jats:italic>APC<\/jats:italic> alterations. This study aimed to evaluate nuclear \u03b2\u2010catenin immunoexpression in scars compared to that in superficial fibromatoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunostaining with an anti\u2010\u03b2\u2010catenin antibody, clone 14, was performed on 8 superficial fibromatoses and 22 scars. The extent of \u03b2\u2010catenin nuclear staining was classified as negative (&lt;10%), focally positive (10\u201049%), or diffusely positive (50\u2010100%). \u03b2\u2010catenin staining intensity was semi\u2010quantitatively graded as weak, moderate, or strong.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 21 (95%) scars, nuclear \u03b2\u2010catenin immunoexpression was detected in fibroblasts\/myofibroblasts, with mainly diffuse (16\/21) and moderate (14\/21) to strong (5\/21) staining. In contrast, seven (88%) of the eight superficial fibromatoses expressed \u03b2\u2010catenin in the nuclei of the lesional spindle cells, at varying levels of staining intensity. Fibroblasts in normal papillary dermis always showed nuclear \u03b2\u2010catenin expression to varying degrees but those in the reticular dermis did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Scars typically exhibit nuclear \u03b2\u2010catenin expression similar to that in superficial fibromatoses. Thus, \u03b2\u2010catenin immunohistochemistry is not suitable for distinguishing superficial fibromatoses from scars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13806","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T19:35:39Z","timestamp":1594496139000},"page":"18-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nuclear \u03b2\u2010catenin immunoexpression in scars"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital  Tokyo Japan"},{"name":"Department of Pathology Itabashi Central Clinical Laboratory  Tokyo Japan"},{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto Japan"},{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute  Osaka Japan"},{"name":"Department of Dermatology Hyogo Cancer Center  Akashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misawo","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital  Yatomi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto Japan"},{"name":"Department of Pathology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto 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