{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:46:27Z","timestamp":1788871587910,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Angiolipoma (AL) is considered as a lipoma variant that is characterized by the combination of mature adipocytes and capillary blood vessels diffusely distributed within the tumor. With the exception of recurrent <jats:italic>PRKD2<\/jats:italic> mutations of uncertain pathogenetic significance, the genetic abnormalities of ALs are unknown, in the absence of any of the specific chromosomal aberrations described in other lipoma variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Formalin\u2010fixed and paraffin\u2010embedded blocks of 13 conventional ALs and 5 cellular ALs from 17 individuals were retrieved and analyzed for mutations in exons 9 and 20 of <jats:italic>PIK3CA<\/jats:italic> by polymerase chain reaction and Sanger sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Activating <jats:italic>PIK3CA<\/jats:italic> mutations were identified in 14 tumors (78%). All <jats:italic>PIK3CA<\/jats:italic>\u2010mutated samples carried the same exon 9 mutation, c.1634A&gt;C (p.E545A). No mutation was detected in exon 20 of <jats:italic>PIK3CA<\/jats:italic>. No significant difference between <jats:italic>PIK3CA<\/jats:italic>\u2010mutated and wild\u2010type samples appeared to exist based on age, gender, and location of the tumor. All 5 cellular ALs carried the p.E545A <jats:italic>PIK3CA<\/jats:italic> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The high frequency of the p.E545A <jats:italic>PIK3CA<\/jats:italic> mutation in both conventional and cellular ALs suggests that activation of the PI3K\/AKT pathway plays a key role in AL pathogenesis and reinforces the concept that cellular AL should be regarded as a variant of AL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13809","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T16:21:43Z","timestamp":1594743703000},"page":"211-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Frequent activating <i>PIK3CA<\/i> mutations in sporadic 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