{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:10:38Z","timestamp":1759342238408,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Demodex folliculorum<\/jats:italic> is a mite that commonly inhabits the pilosebaceous units of facial skin, particularly in a perioral and periorbital distribution. While typically an incidental and asymptomatic parasite, <jats:italic>Demodex<\/jats:italic> spp. are proposed to contribute to the pathogenesis of facial folliculitis, chronic blepharitis and papulopustular rosacea. Reports of demodicosis in anatomic locations other than the face are exceedingly rare. Here we report a 36\u2010year\u2010old woman with symptomatic <jats:italic>Demodex<\/jats:italic> spp. infestation of Fordyce spots of the labia minora. She was referred to dermatology after a 9\u2010month history of tender red bumps on the vulva that would arise and drain over a 24 to 72 hours period, several times per week. Physical examination revealed erythema of the labia minora and introitus with a 4\u2009mm, pink, dome\u2010shaped soft papule on the left labium minus. Wet mount, microbiologic cultures and sexually transmitted infection (STI) screenings were unremarkable. Histopathologic examination revealed a well\u2010circumscribed nodule of suppurative granulomatous inflammation arising in a background of mucosa with Fordyce spots, the majority of which were infiltrated by <jats:italic>Demodex<\/jats:italic> spp. Treatment with oral ivermectin and topical metronidazole cream resulted in a symptom\u2010free period of 22\u2009months. This case represents an unusual presentation of symptomatic <jats:italic>Demodex<\/jats:italic> infestation.<\/jats:p>","DOI":"10.1111\/cup.13816","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T16:31:06Z","timestamp":1595521866000},"page":"1063-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Symptomatic vulvar demodicosis: A case report and review of the literature"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-9724","authenticated-orcid":false,"given":"Matthew L.","family":"Hedberg","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Chibnall","sequence":"additional","affiliation":[{"name":"Department of Dermatology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh A.","family":"Compton","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine in St. Louis  St. Louis Missouri USA"},{"name":"Department of Dermatology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33224-1_80"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33224-1_176"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.335"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12850"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010030051021"},{"issue":"1","key":"e_1_2_4_7_1","first-page":"73","article-title":"Demodex flagellurus sp. n. 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