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Fusions involving<jats:italic>RAF1<\/jats:italic>are exceedingly rare in melanocytic neoplasms, occurring in less than 1% of melanomas, and usually arise in tumors that are wild type for<jats:italic>BRAF<\/jats:italic>,<jats:italic>NRAS<\/jats:italic>, and<jats:italic>NF1<\/jats:italic>. We describe herein a case of acral melanoma with two satellite metastases and sentinel lymph node involvement. The melanoma had a concomitant<jats:italic>KIT<\/jats:italic>variant and<jats:italic>LRRFIP2\u2010RAF1<\/jats:italic>fusion. This constellation of molecular findings has not been reported previously in melanoma. We review the existing literature on melanocytic neoplasms with<jats:italic>RAF1<\/jats:italic>fusions and discuss the potential clinical implications of this genetic event.<\/jats:p>","DOI":"10.1111\/cup.13817","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T11:36:54Z","timestamp":1595504214000},"page":"1181-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Novel<scp><i>LRRFIP2\u2010RAF1<\/i><\/scp>fusion identified in an acral melanoma: A review of the literature on melanocytic proliferations with<scp><i>RAF1<\/i><\/scp>fusions and the potential therapeutic implications"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-0381","authenticated-orcid":false,"given":"Robert E.","family":"LeBlanc","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Geisel School of Medicine 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