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The tumor cells were negative for HMB\u201045 and Melan\u2010A and positive for CK7 and other breast markers (GCDFP15, mammaglobin, and GATA3). While concerning for metastatic melanoma based on clinical history and initial immunohistochemistry, tumor morphology and subsequent immunohistochemistry was supportive of metastatic breast adenocarcinoma. This case demonstrates a rare but perilous diagnostic pitfall of triple\u2010negative breast carcinomas that strongly and diffusely express S\u2010100 protein and SOX10 mimicking melanoma.<\/jats:p>","DOI":"10.1111\/cup.13822","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T05:35:00Z","timestamp":1595655300000},"page":"1187-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["S\u2010100 protein and <scp>SOX10<\/scp>\u2010positive breast carcinoma mimicking metastatic melanoma"],"prefix":"10.1111","volume":"47","author":[{"given":"John","family":"Newman","sequence":"first","affiliation":[{"name":"Emory School of Medicine Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Brahmbhatt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin K.","family":"Stoff","sequence":"additional","affiliation":[{"name":"Department of Dermatology Emory University  Atlanta Georgia USA"},{"name":"Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-3103","authenticated-orcid":false,"given":"Anthony P.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Emory University  Atlanta Georgia USA"},{"name":"Department of Pathology and Laboratory Medicine Emory University  Atlanta Georgia 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