{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:11:13Z","timestamp":1780560673105,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of tumor\u2010to\u2010tumor metastasis of a cutaneous malignant melanoma to a synchronous thyroid Hurthle cell carcinoma. A 42\u2010year\u2010old male underwent a biopsy of right inguinal lymphadenopathy which showed metastatic melanoma. The primary lesion was identified on his right posterior leg, and staging workup discovered a synchronous left thyroid lobe nodule concerning for a follicular neoplasm. He underwent excision of the primary melanoma, right inguinal lymphadenectomy, and total thyroidectomy. The resected thyroid contained a 6.6\u2010cm, well\u2010encapsulated left\u2010sided nodule, red\u2010brown in color and homogenous in consistency, with areas of focal hemorrhage and no grossly identifiable calcification. Microscopically, large tumor cells with distinct cell borders were present, with deeply eosinophilic and granular cytoplasm, large nuclei with prominent nucleoli, and loss of polarity consistent with oncocytes. A microscopic single focus of vascular invasion was identified, and a diagnosis of angioinvasive Hurthle cell carcinoma was made. Within the Hurthle cell carcinoma, multiple deposits of metastatic melanoma were seen. These findings were indicative of tumor\u2010to\u2010tumor metastasis of the cutaneous melanoma to the angioinvasive Hurthle cell carcinoma. Our findings show the ability of melanoma to metastasize to a pre\u2010existing neoplasm.<\/jats:p>","DOI":"10.1111\/cup.13829","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T10:14:27Z","timestamp":1596363267000},"page":"1196-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of <scp>tumor\u2010to\u2010tumor<\/scp> metastasis of cutaneous malignant melanoma"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3576","authenticated-orcid":false,"suffix":"III","given":"Richard J.","family":"Straker","sequence":"first","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-4886","authenticated-orcid":false,"given":"Mitul B.","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia A.","family":"LiVolsi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Fraker","sequence":"additional","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos C.","family":"Karakousis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0154"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02773.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5683-4"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<574::AID-CNCR21>3.0.CO;2-#"},{"issue":"1","key":"e_1_2_4_6_1","first-page":"E7","article-title":"Malignant melanoma metastatic to the thyroid gland: a case report and review of the literature","volume":"88","author":"Kung B","year":"2009","journal-title":"Ear Nose Throat J"},{"issue":"12","key":"e_1_2_4_7_1","first-page":"713","article-title":"Diagnosis of thyroid metastasis of uveal melanoma by fine needle aspiration biopsy","volume":"46","author":"Cagnazzo A","year":"1991","journal-title":"Minerva Chir"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000251"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.18.3.282"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000259613.28127.f8"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02016.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01871.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.08.002"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-009-9087-x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/238693"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-265"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347543"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206757"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/stcs.2002.29534"},{"issue":"2","key":"e_1_2_4_20_1","first-page":"98","article-title":"The distribution of secondary growths in cancer of the breast. 1889","volume":"8","author":"Paget S","year":"1989","journal-title":"Cancer Metastasis Rev"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3010126"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90171-X"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007927"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196809)22:3<635::AID-CNCR2820220320>3.0.CO;2-O"},{"issue":"2","key":"e_1_2_4_25_1","first-page":"135","article-title":"Neoplasm to neoplasm metastasis. An acidophil adenoma harbouring metastatic carcinoma: a case report","volume":"91","author":"Richardson JF","year":"1971","journal-title":"Arch Pathol"},{"issue":"4","key":"e_1_2_4_26_1","first-page":"367","article-title":"Tumor\u2010to\u2010tumor metastasis: pathology and neuroimaging considerations","volume":"5","author":"Moody P","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.2176"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(87)90568-1"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00361"},{"issue":"7","key":"e_1_2_4_30_1","first-page":"601","article-title":"Metastasis of neoplasms to other neoplasms","volume":"5","author":"Ortega P","year":"1951","journal-title":"Ann West Med Surg"},{"issue":"7","key":"e_1_2_4_31_1","first-page":"205","article-title":"Metastatic hypernephroma of the thyroid gland","volume":"28","author":"Beahrs OH","year":"1953","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10901"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.02.022"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13829","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:04:06Z","timestamp":1693875846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,6]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/cup.13829"],"URL":"https:\/\/doi.org\/10.1111\/cup.13829","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,6]]},"assertion":[{"value":"2020-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}