{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:35:57Z","timestamp":1762079757330,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acral inflammatory lesions that have some resemblance to idiopathic or autoimmune\u2010associated perniosis (chilblains) have been described in multiple countries during the COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined histopathologic findings in six consecutive such cases from five patients received in mid\u2010May to mid\u2010June of 2020, evaluating immunohistochemical staining for the SARS\u2010CoV\u20102 nucleocapsid protein. We compared these six cases to eight cases diagnosed as perniosis between January and June of 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five of six lesions with perniosis\u2010like histopathology during the COVID\u201019 pandemic had distinctive tight cuffing of lymphocytes; intravascular material was present in one case. SARS\u2010CoV\u20102 immunohistochemical staining using an antibody directed at the nucleocapsid protein was negative in all six cases. Only one of eight specimens with microscopic findings of perniosis received prior to the COVID\u201019 pandemic had tightly cuffed perivascular lymphocytes, and none had obvious intravascular occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A tightly cuffed pattern of perivascular lymphocytes is a feature of perniosis during the COVID\u201019 pandemic. The absence of SARS\u2010CoV\u20102 nucleocapsid protein in these cases suggests against the virus being directly present in these lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13830","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T18:10:25Z","timestamp":1596478225000},"page":"997-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Perniosis during the <scp>COVID<\/scp>\u201019 pandemic: Negative <scp>anti\u2010SARS\u2010CoV<\/scp>\u20102 immunohistochemistry in six patients and comparison to perniosis before the emergence of <scp>SARS\u2010CoV<\/scp>\u20102"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2270-2524","authenticated-orcid":false,"given":"Christine J.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Dermatology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"},{"name":"Department of Pathology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malini","family":"Harigopal","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Damsky","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"},{"name":"Department of Pathology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-1105","authenticated-orcid":false,"given":"Jeff R.","family":"Gehlhausen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Bosenberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"},{"name":"Department of Pathology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Patrignelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"McNiff","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"},{"name":"Department of Pathology Yale Department of Dermatology, Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14227"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16682"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14215"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.05.145"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14243"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14937"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.093"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19163"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.04.011"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.09.020"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90038-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117861"},{"key":"e_1_2_5_14_1","unstructured":"SigalAC ZirnJR LipperGM ShapiroPE. 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