{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:41:05Z","timestamp":1778845265430,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fusions involving the <jats:italic>BRAF<\/jats:italic> gene are responsible for 5% of Spitz neoplasms. To better characterize them, we report the clinical, morphological, and genomic findings of six <jats:italic>BRAF<\/jats:italic> fusion Spitz tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The morphological, clinical, and molecular findings of six <jats:italic>BRAF<\/jats:italic> fusion Spitz neoplasms assessed by next generation sequencing (NGS) were compared to a control set of Spitz without <jats:italic>BRAF<\/jats:italic> fusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>BRAF<\/jats:italic> fusion Spitz tumors had frequent predominance of epithelioid morphology (4\/6 cases), frequent high\u2010grade nuclear atypia and pleomorphism (5\/6 cases), and a frequent desmoplastic base (3\/6 cases). Five of six cases were diagnosed as atypical Spitz tumor and one as Spitz nevus. All cases had uneventful clinical follow\u2010up. There were five different fusion partners, with <jats:italic>CLIP2<\/jats:italic> being the most frequent. Secondary pathogenic mutations were frequent and chromosomal copy number changes were seen in three of six cases by an NGS platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>BRAF<\/jats:italic> fusions Spitz usually have epithelioid morphology, high\u2010grade nuclear atypia, and desmoplasia. Chromosomal copy number changes are not infrequent. While our cases had uneventful follow\u2010up, a meta\u2010analysis of the literature suggests that among the fusion subtypes associated with Spitz tumors, they are among the subgroups more likely to develop distant metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13842","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T04:43:07Z","timestamp":1597034587000},"page":"1132-1142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<i>BRAF<\/i> fusion Spitz neoplasms; clinical morphological, and genomic findings in six cases"],"prefix":"10.1111","volume":"47","author":[{"given":"Daniel","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha U.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsy V.","family":"Compres","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel C.","family":"Sunshine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor L.","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6194-1037","authenticated-orcid":false,"given":"Pedram","family":"Gerami","sequence":"additional","affiliation":[{"name":"Department of Dermatology Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"},{"name":"Robert H. 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