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Silver nitrate darkens with exposure to light, and the area can appear to change over time. On microscopic examination, there are coarse pigmented granules dispersed throughout the corneal layer, and largely absent from the remainder of the epidermis\u2014although the precise location may depend on the duration of topical exposure. While argyria, its irreversible counterpart, has been well\u2010characterized, only a single source has previously reported the histopathology of transient topical silver nitrate exposure. We present two cases, review the clinical and histopathologic differentials, and detail the distinctive histopathology that enables a diagnosis to be suggested in this clinical mimicker of melanoma.<\/jats:p>","DOI":"10.1111\/cup.13851","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T09:51:14Z","timestamp":1597657874000},"page":"1205-1210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A clinical mimicker of melanoma with distinctive histopathology: Topical silver nitrate exposure"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-2507","authenticated-orcid":false,"given":"Regina M.","family":"Ondrasik","sequence":"first","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center Department of Pathology and Laboratory Medicine  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Jordan","sequence":"additional","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center Department of Pathology and Laboratory Medicine  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravindhan","family":"Sriharan","sequence":"additional","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center Department of Pathology and Laboratory Medicine  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"issue":"3","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/01.ta.0000208126.22089.b6","article-title":"Silver\u2010coated dressing Acticoat caused raised liver enzymes and argyria\u2010like symptoms in burn patient","volume":"60","author":"Trop M","year":"2006","journal-title":"J Trauma"},{"issue":"4","key":"e_1_2_5_3_1","first-page":"197","article-title":"Semi\u2010permanent skin staining associated with silver\u2010coated wound dressing Acticoat","volume":"27","author":"Zweiker D","year":"2014","journal-title":"Ann Burn Fire Disasters"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/146642409811800618"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.11.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.08.007"},{"key":"e_1_2_5_7_1","unstructured":"EmanuelP.Silver nitrate pigmentation pathology.2020. 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