{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:22:52Z","timestamp":1783419772711,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The epidermal basement membrane (BM) is readily identified on skin biopsy specimens stained with periodic acid\u2010Schiff (PAS) and PAS with diastase (PAS\u2010D). Thickening of BM can be evidenced in several inflammatory and tumoral conditions. We noticed that most of our biopsy specimens of mycosis fungoides (MF) showed thickening of the BM. We decided to retrospectively study BM thickness in 27 biopsy specimens of MF and compare them with 27 cutaneous biopsy specimens of inflammatory diseases. We studied PAS and PAS\u2010D stains in all cases and we measured BM thickness with an ocular micrometer. Cases were scored in a four\u2010tiered system: 0: no detectable staining; 1+ (mild: &lt;\u20095 \u03bcm); 2+ (moderate: 5\u20109 \u03bcm); and 3+ (prominent: &gt;9 \u03bcm). The difference between both groups (MF vs controls) was highly significant for BM thickness values by both one\u2010 and two\u2010tailed <jats:italic>t<\/jats:italic> tests (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0006). While only 3 biopsy specimens from the controls (11.11%) showed areas of 3+ thickening, 12 biopsy specimens of MF (44.44%) showed areas of 3+ thickening, and most cases showed diffuse, at least 2+ thickening, while the controls showed more segmental, mostly 1 or 2+ staining. We conclude that thickening of BM can be useful in the differential diagnosis with inflammatory conditions.<\/jats:p>","DOI":"10.1111\/cup.13853","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T08:24:52Z","timestamp":1598171092000},"page":"356-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thickening of the basement membrane as a diagnostic sign of mycosis fungoides"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-2364","authenticated-orcid":false,"given":"Angel","family":"Fernandez\u2010Flores","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Hospital Universitario El Bierzo  Ponferrada Spain"},{"name":"Department of Cellular Pathology Hospital de la Reina  Ponferrada Spain"},{"name":"Research Department. Institute for Biomedical Research of A Coru\u00f1a (INIBIC) University of A Coru\u00f1a (UDC)  A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-5728","authenticated-orcid":false,"given":"My","family":"Diep","sequence":"additional","affiliation":[{"name":"Western University of Health Sciences, College of Osteopathic Medicine of the Pacific  Pomona California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-0858","authenticated-orcid":false,"given":"David","family":"Cassarino","sequence":"additional","affiliation":[{"name":"Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente Department of Dermatology  Los Angeles California 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