{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:45:05Z","timestamp":1769168705121,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Melanoma is known to show considerable variation in its histopathological presentation. In exceptional cases, heterologous or divergent differentiation (metaplastic melanoma) can be observed. We report a case of a 69\u2010year\u2010old man who was diagnosed with nodular melanoma on the right upper leg. One year later, the patient presented with an inguinal lymph node metastasis and a lymph node dissection was carried out. In two out of five positive lymph nodes, an angiosarcomatous component was found next to a conventional melanoma component. Shortly after, the patient developed two in\u2010transit metastases in which again an angiosarcomatous component was seen. The vascular component stained positive for ERG and CD31 and negative for melanocytic markers (Mart\u20101, S100, SOX\u201010), while the conventional melanoma had an opposite staining pattern. Molecular analysis on both components showed an identical mutation in the <jats:italic>NRAS<\/jats:italic> gene, which in our opinion proves the divergent differentiation. To the best of our knowledge, this is the first case report describing angiosarcomatous transdifferentiation of melanoma.<\/jats:p>","DOI":"10.1111\/cup.13857","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T15:04:46Z","timestamp":1598886286000},"page":"1211-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Angiosarcomatous transdifferentiation of metastatic melanoma"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-6164","authenticated-orcid":false,"given":"Melvin J.","family":"Kilsdonk","sequence":"first","affiliation":[{"name":"Department of Pathology University Medical Centre Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonnis R.","family":"Romeijn","sequence":"additional","affiliation":[{"name":"Department of Pathology Martini Hospital  Groningen 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