{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:47:16Z","timestamp":1777355236302,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with primary immunodeficiency are at increased risk for malignancy, especially hematologic neoplasms. This paper reports a unique case of a 47\u2010year\u2010old man with X\u2010linked agammaglobulinemia who presented with progressive asymptomatic violaceous papules and plaques on his face, hands, and trunk for 1 year. Skin biopsies revealed deep, nodular infiltrates of histiocytes and CD8\u2010positive lymphocytes, with a CD4:CD8 ratio of 1:10. Laboratory studies showed cytopenias. Flow cytometry in the skin, blood, and bone marrow (BM) showed a CD3+\/CD8+\/CD57+ large granular lymphocyte population. BM biopsy showed 30% involvement with these atypical T\u2010cells. T\u2010cell gene rearrangement studies of skin, blood, and BM revealed identical T\u2010cell clones. He was diagnosed with T\u2010large granular lymphocyte leukemia (T\u2010LGLL) with an associated CD8+ cutaneous lymphoproliferation. Skin involvement was suspected to represent infiltration by T\u2010LGLL. However, co\u2010existence of two lymphoproliferative disorders (LPDs), T\u2010LGLL and CD8+ granulomatous LPD, remains a possibility. In general, cutaneous infiltrates associated with LGLL are rare and poorly understood. It has been suggested that they are markers of poor prognosis. Our case report describes skin, blood, and BM findings in an immunosuppressed patient with T\u2010LGLL in detail. These findings have not yet been reported and their significance requires further investigation.<\/jats:p>","DOI":"10.1111\/cup.13860","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T07:17:14Z","timestamp":1599203834000},"page":"567-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>CD8<\/scp>\u2010positive cutaneous lymphoproliferation associated with large granular lymphocyte leukemia in a patient with X\u2010linked agammaglobulinemia"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-1590","authenticated-orcid":false,"given":"Hala","family":"Daou","sequence":"first","affiliation":[{"name":"Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh A.","family":"Hatch","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Weinkle","sequence":"additional","affiliation":[{"name":"Department of Dermatology Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Eli","family":"Morey","sequence":"additional","affiliation":[{"name":"Department of Pathology Moffitt Center and Research Institute  Tampa Florida USA"},{"name":"Department of Cutaneous Oncology Moffitt Center and Research Institute  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-0224","authenticated-orcid":false,"given":"Jane","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Pathology Moffitt Center and Research Institute  Tampa Florida USA"},{"name":"Department of Cutaneous Oncology Moffitt Center and Research 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