{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:37:07Z","timestamp":1791221827650,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 21\u2010year\u2010old female presented with a 5\u2010year history of an erythematous papule on her right breast. The biopsy showed a dense, dermal nodular infiltrate, extending focally into the subcutaneous tissue. The infiltrate was composed predominantly of pleomorphic cells with bi\u2010lobed, multi\u2010lobed, horseshoe, or ring\u2010shaped nuclei. There was a smaller subset of monomorphous cells characterized by a round, reniform, or elongated single\u2010lobed nucleus. Accompanying cells included few foamy histiocytes, lymphocytes, and numerous scattered eosinophils. No necrosis, vascular invasion, or ulceration was present. The pleomorphic and monomorphic granular cells were positive for Giemsa stain as well as for tryptase, CD117, CD68, CD2, and CD30 immunohistochemistry and negative for S100, CD1a, myeloperoxidase, lysozyme, and CD56. Clinical examination was negative for any additional similar lesions and serum tryptase was within normal limits. The bone marrow was not biopsied. In addition, fluorescent in situ hybridization revealed multiple clones with loss of number 5 chromosome and <jats:italic>PDGFRA<\/jats:italic> and <jats:italic>HRAS<\/jats:italic> mutations. The lesion did not recur or progress after a 6\u2010year clinical follow\u2010up. To our full knowledge, we report the first case of pleomorphic mastocytoma with loss of chromosome 5 and <jats:italic>PDGFRA<\/jats:italic> and <jats:italic>HRAS<\/jats:italic> mutations.<\/jats:p>","DOI":"10.1111\/cup.13868","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T17:05:23Z","timestamp":1602522323000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pleomorphic mastocytoma associated with loss of chromosome 5, <scp><i>PDGFRA<\/i>,<\/scp> and <scp><i>HRAS<\/i><\/scp> mutations: A case of cutaneous mastocytosis with severe atypia and indolent behavior"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-3100","authenticated-orcid":false,"given":"Mariantonieta","family":"Tirado","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M.","family":"Dobin","sequence":"additional","affiliation":[{"name":"Department of Pathology Baylor Scott and White Health  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pathology Baylor Scott and White Health  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arundhati","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology Baylor Scott and White Health  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"61","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000768"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200212000-00006"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01257.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01905.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13080"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10816.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.224"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.550072"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2798"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.03.014"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.031690"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3306"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.13868","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:08:40Z","timestamp":1692965320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,12]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/cup.13868"],"URL":"https:\/\/doi.org\/10.1111\/cup.13868","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,12]]},"assertion":[{"value":"2020-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}