{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:31Z","timestamp":1779400651420,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present study aimed to analyze the histopathologic aspects of cases diagnosed as chronic hyperplastic candidiasis (CHC) in an oral pathology service, pointing out the most important features found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All cases histopathologically diagnosed as CHC between 2002 and 2018 were retrieved from the files of the service. Data of the patients and the lesions were collected. Histopathological analysis was performed to evaluate the microscopic characteristics and the amount of <jats:italic>Candida<\/jats:italic> present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six cases of CHC were retrieved. Women were more affected and there was a predilection for Whites. Most lesions appeared as a nodule or a white plaque, asymptomatic, on the tongue or buccal mucosa. Histopathologically, statistical significance was noted for the presence of epithelial hyperplasia, exocytosis, and mononuclear inflammatory infiltrate. Interestingly, only the association between dysplasia and the amount of fungus was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CHC appears to be a distinct entity presenting typical histopathologic aspects. CHC might even show epithelial dysplasia. In those cases, the presence of a large amount of <jats:italic>Candida<\/jats:italic> together with other histopathological features should lead to the diagnosis of CHC and subsequent treatment. However, close follow up is important.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13875","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T02:05:52Z","timestamp":1600308352000},"page":"66-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Histopathologic aspects of the so\u2010called chronic hyperplastic candidiasis: An analysis of 36 cases"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8205-9935","authenticated-orcid":false,"given":"Paulo S\u00e9rgio Souza","family":"Pina","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry University of S\u00e3o Paulo (FOUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-9494","authenticated-orcid":false,"given":"Marcos","family":"Cust\u00f3dio","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry University of S\u00e3o Paulo (FOUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-6295","authenticated-orcid":false,"given":"Norberto Nobuo","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry, University of S\u00e3o Paulo (FOUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-9608","authenticated-orcid":false,"given":"Suzana Cantanhede Orsini Machado","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry University of S\u00e3o Paulo (FOUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1997.tb00026.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.02.022"},{"key":"e_1_2_6_4_1","first-page":"112","volume-title":"WHO Classification of Head and Neck Tumours","author":"Reibel J","year":"2017"},{"key":"e_1_2_6_5_1","first-page":"103","article-title":"Aspects peu connus de candidosis buccales. 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