{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:17:10Z","timestamp":1792181830365,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult\u2010onset inflammatory linear verrucous epidermal nevus (ILVEN) is an uncommon cutaneous disease compared to childhood\u2010onset ILVEN. The typical histopathologic features are alternating parakeratosis and orthokeratosis with an absent granular layer underneath parakeratosis, in contrast to a thickened granular layer below the foci of orthokeratosis in psoriasiform epidermal hyperplasia. Herein, we present a 49\u2010year\u2010old woman with typical clinical and histopathologic characteristics of adult\u2010onset ILVEN, including linear arrangement of thick scaly papules and plaques localized on the medial side of her right leg, ankle, and foot. Immunohistochemical studies included involucrin, Ki\u201067, and keratin\u201010. Compared to the staining pattern in psoriasis, the expression of involucrin in this case was of lower intensity and localized to upper epidermal layers with relatively less extensive staining beneath regions of parakeratosis as compared to orthokeratosis; Ki\u201067 showed lower basal layer proliferative activity; and keratin\u201010 showed a greater intensity of staining within suprabasal epidermis.<\/jats:p>","DOI":"10.1111\/cup.13881","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T02:30:25Z","timestamp":1600655425000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adult\u2010onset inflammatory linear verrucous epidermal nevus: Immunohistochemical studies and review of the literature"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3294-6717","authenticated-orcid":false,"given":"Hui\u2010Wen","family":"Tseng","sequence":"first","affiliation":[{"name":"Department of Dermatology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"Institute of Biomedical Sciences, National Sun Yat\u2010Sen University  Kaohsiung Taiwan"},{"name":"Department of Health and Beauty Shu\u2010Zen Junior College of Medicine and Management  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Bin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010An","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000220043008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2001.00530.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.169132"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000200054009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251404"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640150072021"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1978.tb01501.x"},{"issue":"4","key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2340\/0001555571343346","article-title":"Inflammatory linear verrucous epidermal naevus (ILVEN) versus linear psoriasis. 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