{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:19:53Z","timestamp":1777713593701,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (MF), the commonest primary cutaneous T\u2010cell lymphoma, has classic and variant types which include hypopigmented MF (HMF). Previous studies have identified distinct clinicopathological profiles in HMF. This study aims to objectively compare the clinicopathological features of HMF with non\u2010HMF lesions in order to characterize salient features of HMF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional, retrospective study analyzed biopsy specimens of 87 patients with MF. HMF and non\u2010HMF groups were compared using clinical data, immunophenotypic features and scores given for six histopathological features: dermal infiltrate, basilar and superficially extending epidermotropism, Pautrier microabscesses and dermal and epidermotropic lymphocytic atypia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010six patients had HMF. Presentation in females (59.21%; <jats:italic>p<\/jats:italic> = .04) and patch stage (88.16%; <jats:italic>p<\/jats:italic> = .01) in HMF were significant, and HMF presented at a younger mean age when compared to non\u2010HMF. Both groups had equal intensity of epidermotropism, with HMF showing milder dermal infiltrates and significantly less dermal atypia. Pautrier microabscesses were significantly commoner in non\u2010HMF (LR 10.76; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). 94.74% of HMF were CD4\u2212\/CD8+.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HMF presents at a lower age and earlier stage with female predominance compared to non\u2010HMF. Because of milder dermal infiltrates, less dermal atypia, and Pautrier microabscesses, the diagnosis of HMF requires correlation with clinical features and careful assessment of epidermotropic cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13882","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T14:04:28Z","timestamp":1600869868000},"page":"486-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison between the histopathological and immunophenotypical features of hypopigmented and nonhypopigmented mycosis fungoides: A retrospective study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-7719","authenticated-orcid":false,"given":"Dinesha Ruwanthi","family":"Jayasinghe","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine University of Colombo  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karuna","family":"Dissanayake","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital of Sri Lanka  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mannikawadumesthri Vipula Chandu","family":"de Silva","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine University of Colombo  Colombo Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-012-0038-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.11648\/j.sjcm.20140304.12"},{"key":"e_1_2_11_4_1","first-page":"226","volume-title":"WHO Classification of Skin Tumours","author":"Cerroni L","year":"2018"},{"key":"e_1_2_11_5_1","first-page":"231","volume-title":"WHO Classification of Skin Tumours","author":"Cerroni L","year":"2018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20132336"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2016.04.004"},{"key":"e_1_2_11_8_1","unstructured":"McNiffJM. 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