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Spitz neoplasms with <jats:italic>ALK<\/jats:italic> rearrangements frequently demonstrate polypoid growth with a plexiform arrangement of nested, fusiform melanocytes in intersecting fascicles. Although neurotropism has been described in indolent Spitz neoplasms, this feature is not frequently mentioned in publications on histopathologic assessment of this group of melanocytic tumors. Here, we present an unusual case of a 3\u2010year\u2010old female with an ALK\u2010positive compound Spitz nevus with extensive perineural and intraneural neurotropism occurring on the vermilion border of the lower lip.<\/jats:p>","DOI":"10.1111\/cup.13890","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T03:21:36Z","timestamp":1602213696000},"page":"154-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>ALK<\/scp>\u2010positive compound Spitz nevus with extensive perineural and intraneural neurotropism"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-7227","authenticated-orcid":false,"given":"Ryanne A.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Pathology Stanford Medicine  Stanford California USA"},{"name":"Department of Dermatology Stanford Medicine  Stanford California USA"},{"name":"Department 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