{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:01:59Z","timestamp":1791234119644,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaplastic lymphoma kinase (<jats:italic>ALK<\/jats:italic>) rearranged lung cancers represent 4% to 6% of all pulmonary adenocarcinomas, and echinoderm microtubule associated protein like 4 (<jats:italic>EML4<\/jats:italic>)\u2010<jats:italic>ALK<\/jats:italic> fusions are the most common subgroup. Herein, we report a case of two successive drug reactions due to ALK inhibitors. A 69\u2010year\u2010old female with stage IVB <jats:italic>EML4\u2010ALK<\/jats:italic> fused lung adenocarcinoma developed a generalized morbilliform eruption 10\u2009days after starting alectinib. Skin biopsy findings were consistent with a drug reaction. Her findings resolved after alectinib was discontinued. Another ALK inhibitor, lorlatinib was started and she developed multiple asymptomatic cutaneous and oral nodules 4 months later. Biopsies from these nodules showed sarcoidal granulomas without evidence of metastases or infection. ALK inhibitors are associated with numerous adverse events, including various cutaneous eruptions. However, a sarcoidal drug reaction involving the skin has not been reported. Identification of drug reactions to targeted therapy can avoid long\u2010term sequelae and misinterpretation of the clinical findings as disease progression or infection.<\/jats:p>","DOI":"10.1111\/cup.13911","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T15:17:19Z","timestamp":1604157439000},"page":"425-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cutaneous sarcoid\u2010like drug reaction caused by an <scp>anaplastic lymphoma kinase<\/scp> inhibitor"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3144-6318","authenticated-orcid":false,"given":"Casey A.","family":"Gleue","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabeer","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Mary's Hospital  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Wentworth","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Bridges","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.07.025"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2117-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2291"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3580"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12613"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704795"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1256"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1006448"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000350"},{"issue":"6","key":"e_1_2_5_11_1","first-page":"403","article-title":"Crizotinib\u2010induced lichenoid drug eruption in a patient with lung cancer","volume":"102","author":"Ho YH","year":"2018","journal-title":"Cutis"},{"issue":"9","key":"e_1_2_5_12_1","first-page":"73","article-title":"Hypersensitivity in ALK\u2010positive lung cancers exposed to ALK inhibitors: a case of successful switch to an alternative ALK inhibitor and systematic review of the literature","volume":"9","author":"Deng L","year":"2018","journal-title":"Lung Cancer (Auckl)"},{"key":"e_1_2_5_13_1","unstructured":"Pfizer.Lorbrena (lorlatinib) [package insert]. 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