{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:17:40Z","timestamp":1791487060003,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Secondary angiosarcoma (AS) most commonly follows breast cancer and includes postirradiation AS (PRAS) and lymphedema\u2010associated AS. The frequent amplification of <jats:italic>MYC<\/jats:italic> (8q24.21) in secondary AS and the rising incidence of PRAS and atypical vascular lesions (AVLs) have prompted interest in the diagnostic and prognostic utility of <jats:italic>MYC<\/jats:italic> in AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective series with \u22652 cases of cutaneous AS and describing the use of fluorescence in situ hybridization (FISH) for <jats:italic>MYC<\/jats:italic> amplification or immunohistochemistry (IHC) for MYC overexpression were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen studies met inclusion criteria. Overall, 93% of cases evaluated by FISH and IHC were concordant. The sensitivity of FISH in primary AS was only 6.8%, and protein overexpression occurred without amplification in sun\u2010damaged skin. FISH and IHC were over 78% sensitive in secondary AS but negative in over 98% of AVLs. <jats:italic>MYC<\/jats:italic> amplification and <jats:italic>FLT4<\/jats:italic> coamplification were associated with shorter overall survival in secondary AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FISH for <jats:italic>MYC<\/jats:italic> amplification and IHC for MYC overexpression are useful in distinguishing PRAS from AVLs and may also have prognostic value in secondary AS. In contrast, these methods have little diagnostic or prognostic value in primary AS and should not be used to distinguish primary AS from benign vascular neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13912","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T15:38:59Z","timestamp":1604158739000},"page":"578-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<scp><i>MYC<\/i><\/scp> gene amplification by fluorescence in situ hybridization and <scp>MYC<\/scp> protein expression by immunohistochemistry in the diagnosis of cutaneous angiosarcoma: Systematic review and appropriate use criteria"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-0826","authenticated-orcid":false,"given":"Kiran","family":"Motaparthi","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Florida College of Medicine  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Lauer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-4947","authenticated-orcid":false,"given":"Rajiv M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Michigan Medicine Department of Pathology University of Michigan  Ann Arbor Michigan USA"},{"name":"Michigan Medicine Department of Dermatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-4974","authenticated-orcid":false,"given":"Claudia I.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Dermatology Center of Southern Indiana  Bloomington Indiana 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