{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:54:08Z","timestamp":1784170448066,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diatoms are photosynthetic algae with a siliceous exoskeleton. Diatoms are utilized by a wide array of industries for applications such as filtration and pest control. Unsubstantiated claims have also propelled their societal reach to trendy oral and topical uses. This case highlights a rare case of an oral granuloma secondary to diatoms. An 80\u2010year\u2010old woman presented with a mobile, firm, asymptomatic submucosal mass on her lower left mandibular vestibular mucosa. Histopathology showed a non\u2010caseating granulomatous reaction to diatoms. Her only verified contact with a diatomaceous earth product was a dental impression using alginate after upper front teeth trauma 5\u2009months before. Although there have been several cases of allergic contact dermatitis attributed to diatoms, there are no reported cases of diatom\u2010induced granuloma formation found in the literature. There are, however, ample data on granulomas initiated by silica. Given the silica\u2010based composition of diatoms, and the broad use of diatoms in industry and alternative medicine, it is unclear why diatom\u2010induced granulomas are not more widely described. This report may alert clinicians to the existence of diatom granulomas and incline them to tailor their history to cover questions about possible exposure when evaluating patients presenting with a localized oral lesion.<\/jats:p>","DOI":"10.1111\/cup.13922","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T09:04:22Z","timestamp":1605949462000},"page":"429-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of oral foreign\u2010body granuloma due to diatoms"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-7912","authenticated-orcid":false,"given":"Gabrielle","family":"Brody","sequence":"first","affiliation":[{"name":"University of California, Irvine, School of Medicine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Yale","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee J.","family":"Slater","sequence":"additional","affiliation":[{"name":"Scripps Oral Pathology Service  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Lanzon","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery  Lompoc California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Carey","sequence":"additional","affiliation":[{"name":"Lompoc Dentistry  Lompoc California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Ragsdale","sequence":"additional","affiliation":[{"name":"Western Pathology, Inc  San Luis Obispo California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1","volume-title":"The Diatoms. 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